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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Spectazole

$17.331 tube (30g) 1% cream
price without discount in nearest pharmacy. Price may vary.

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Econazole volume of distribution

After topical application to the skin of normal subjects, systemic absorption of econazole nitrate is extremely low. Although most of the applied drug remains on the skin surface, drug concentrations were found in the stratum corneum which, by far, exceeded the minimum inhibitory concentration for dermatophytes.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Econazole

A broad spectrum antimycotic with some action against Gram positive bacteria. It is used topically in dermatomycoses also orally and parenterally.

Econazole mechanism of action

Econazole interacts with 14-alpha; demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Econazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

Dosage forms of Econazole

FormRouteStrength
Creamtopical10 mg/g
Creamtopical10 mg/1
Creamtopical1 %

Prescription Generics

true

International Brands

Econazole Nitrate

Synonyms

(+-)-Econazole 1-(2,4-Dichloro-beta-((P-chlorobenzyl)oxy)phenethyl)imidazole

Manufacturers

E. Fougera Co. a division of Fougera Pharmaceuticals Inc.

CAS number

27220-47-9

UNII

6Z1Y2V4A7M

State

solid

Affected organisms

Yeast and other fungi

Indication of Econazole

For topical application in the treatment of tinea pedis, tinea cruris, and tinea corporis caused by iTrichophyton rubrum /i, iTrichophyton mentagrophytes /i, iTrichophyton tonsurans /i, iMicrosporum canis /i, iMicrosporum audouini /i, iMicrosporum gypseum /i, and iEpidermophyton floccosum /i, in the treatment of cutaneous candidiasis, and in the treatment of tinea versicolor.

Toxicity of Econazole

Overdosage of econazole in humans has not been reported to date. In mice, rats guinea pigs and dogs, the oral LD 50 values were found to be 462, 668, 272, and 160 mg/kg, respectively.

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