Save up -80% on Eculizumab
Note: this is a drug discount program, not an insurance plan.
2018 Price of Eculizumab
Soliris 300 mg/30 ml vial
* price without discount in nearest pharmacy. Price may vary.
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Eculizumab volume of distribution
* 7.7 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Eculizumab
Soliris is a formulation of eculizumab which is a recombinant humanized monoclonal IgG2/4;kappa; antibody produced by murine myeloma cell culture and purified by standard bioprocess technology. Eculizumab contains human constant regions from human IgG2 sequences and human IgG4 sequences and murine complementarity-determining regions grafted onto the human framework light- and heavy-chain variable regions. Eculizumab is composed of two 448 amino acid heavy chains and two 214 amino acid light chains and has a molecular weight of approximately 148 kDa.
Eculizumab mechanism of action
A genetic mutation in PNH patients leads to the generation of populations of abnormal RBCs (known as PNH cells) that are deficient in terminal complement inhibitors (CD-59), rendering PNH RBCs sensitive to persistent terminal complement-mediated destruction. The destruction and loss of these PNH cells (intravascular hemolysis) results in low RBC counts (anemia) and also fatigue, difficulty in functioning, pain, dark urine, shortness of breath, and blood clots. Eculizumab, the active ingredient in Soliris, is a monoclonal antibody that binds to the complement protein C5 specifically and with high affinity, thereby inhibiting its cleavage to C5a and C5b and subsequent generation of the terminal complement complex C5b-9. Soliris inhibits terminal complement mediated intravascular hemolysis in PNH patients and therefore the destruction of PNH erythrocytes that lack complement protection with CD-59.
Dosage forms of Eculizumab
|Concentrate for solution for infusion||Intravenous use||300 mg|
|Injection, solution, concentrate||intravenous||300 mg/30mL|
Alexion Pharmaceuticals Inc.
Humans and other mammals
Indication of Eculizumab
For the treatment of patients with paroxysmal nocturnal hemoglobinuria (PNH) to reduce hemolysis.
Toxicity of Eculizumab
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