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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Efavirenz

Sustiva 50 mg capsule

$1.84

capsule

* price without discount in nearest pharmacy. Price may vary.

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Efavirenz volume of distribution

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What is Efavirenz

Efavirenz (brand names Sustiva and Stocrin) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.

Efavirenz mechanism of action

Similar to zidovudine, efavirenz inhibits the activity of viral RNA-directed DNA polymerase (i.e., reverse transcriptase). Antiviral activity of efavirenz is dependent on intracellular conversion to the active triphosphorylated form. The rate of efavirenz phosphorylation varies, depending on cell type. It is believed that inhibition of reverse transcriptase interferes with the generation of DNA copies of viral RNA, which, in turn, are necessary for synthesis of new virions. Intracellular enzymes subsequently eliminate the HIV particle that previously had been uncoated, and left unprotected, during entry into the host cell. Thus, reverse transcriptase inhibitors are virustatic and do not eliminate HIV from the body. Even though human DNA polymerase is less susceptible to the pharmacologic effects of triphosphorylated efavirenz, this action may nevertheless account for some of the drug’s toxicity.

Dosage forms of Efavirenz

DrugDosageQuantityPrice
Efavirenz600mg30 Capsule$162.00
Efavirenz600mg90 Capsule$465.00
Efavirenz/Emtricitabine/Tenofovir600/200/300mg30 Tablet$106.70
Efavirenz/Emtricitabine/Tenofovir600/200/300mg90 Tablet$298.25
Prescription Generics

false

International Brands

Atripla

Synonyms

(-)-6-CHLORO-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-2H-3,1-benzoxazin-2-one (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one

Manufacturers

A S Medication Solutions

CAS number

154598-52-4

UNII

JE6H2O27P8

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Efavirenz

For use in combination treatment of HIV infection (AIDS)

Toxicity of Efavirenz

RX24 Drugs Disclaimer: before buying a Efavirenz on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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