Save up -80% on Efinaconazole
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Jublia
|$575.49||1 bottle (4ml) 10%|
|price without discount in nearest pharmacy. Price may vary.|
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Efinaconazole volume of distribution
Administration of Jublia by the topical route leads to low systemic efinaconazole concentrations. Systemic absorption of efinaconazole in 18 patients with severe onychomycosis was determined after application of Jublia once daily for 28 days to patients’ 10 toenails and adjacent skin. The concentration of efinaconazole in plasma was determined at multiple time points over the course of 24-hour periods on days 1, 14, and 28. Efinaconazole mean plasma Cmax on Day 28 was 0.67 ng/mL. The mean plasma concentration versus time profile was generally flat over the course of treatment. In onychomycosis patients, the steady state plasma concentration range was 0.1-1.5 ng/mL for efinaconazole and 0.2-7.5 ng/mL for H3 metabolite.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Efinaconazole
Efinaconazole is a 14 alpha-demethylase inhibitor indicated in the treatment of fungal infection of the nail, known as onychomycosis. It was approved for use in Canada and the USA in 2014 and is marketed by Valeant Pharmaceuticals North America LLC under the name Jublia.
Efinaconazole mechanism of action
Efinaconazole is an azole antifungal. Efinaconazole inhibits fungal lanosterol 14 -demethylase involved in the biosynthesis of ergosterol, a constituent of fungal cell membranes.
Dosage forms of Efinaconazole
|Jublia||10%||1 bottle (4ml)||$593|
|Jublia||10%||1 bottle (8ml)||$1,146|
Valeant Canada Lp Valeant Canada S.E.C.
Candida albicans and other yeasts
Indication of Efinaconazole
Indicated in the treatment of fungal infection of the nail, known as onychomycosis.
Toxicity of Efinaconazole
Efinaconazole 10% solution did not cause contact sensitization and induced only minimal skin irritation in human studies. Efinaconazole was generally well tolerated in rats with repeated daily doses of up to 30 (males) and 40 (females) mg/kg. In 13 week dermal toxicity in mice, an increase in liver weight and minimal to mild panlobular hepatocellular hypertrophy was observed, the local application of the drug and/or the vehicle alone resulted in higher incidences of hyperkeratosis, epidermal hyperplasia, and mononuclear infiltrates in the treated skin. Higher concentration of the test article were associated with higher severity of these cutaneous changes compared to controls, and a low incidence of the formation of erosion/ulcers at the treated site. Efinaconazole 10% solution applied intratympanically to the guinea pig middle ear caused significant middle ear inflammation and hearing impairment. In dermal toxicity studies, efinaconazole was well tolerated in minipigs at doses up to 150-200 mg /kg/day.
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What is a Jublia?
Jublia is an antifungal drug that fights fungal infections. It is also used to treat a fungal infection on the toe, called onychomycosis. Jublia is a clear, colorless to pale yellow solution, supplied in a white plastic bottle using a flow brush applicator.
Jublia is for external use only and is not intended for ophthalmic, oral or intravaginal use. It is intended for use only on toenails and immediately adjacent skin.
Avoid pedicures, nail polish and cosmetic products for nails when using Jublia. Follow all directions on label and package. Tell each of your health care providers about all your medical conditions, allergies, and all medications you use.