Save up -80% on Eflornithine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vaniqa

$172.741 tube (45g) 13.9% cream
price without discount in nearest pharmacy. Price may vary.

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We offer free Vaniqa coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Eflornithine every time. What are you waiting for? Claim your prescription drug card now!

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Eflornithine volume of distribution

Clearance and volume of distribution for eflornithine have previously been reported at 2 mL/min/kg and 0.35 L/kg, respectively in man. Eflornithine has a oral bioavailability of 54% in man and about 50% in the rat, when analysed with nonstereoselective analysis.

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What is Eflornithine

Eflornithine is a prescription drug indicated in the treatment of facial hirsutism (excessive hair growth). Eflornithine hydrochloride cream for topical application is intended for use in women suffering from facial hirsutism and is sold by Allergan, Inc. under the brand name Vaniqa. Besides being a non-mechanical and non-cosmetic treatment, eflornithine is the only non-hormonal and non-systemic prescription option available for women who suffer from facial hirsutism. Eflornithine for injection against sleeping sickness was manufactured by Sanofi Aventis and sold under the brand name Ornidyl in the USA. It is now discontinued. Eflornithine is on the World Health Organization’s List of Essential Medicines.

Eflornithine mechanism of action

Eflornithine prevents hair growth by inhibiting the anagen phase of hair production. This occurs by eflornithine irreversibly binding (also called suicide inhibition) to ornithine decarboxylase (ODC) and physically preventing the natural substrate ornithine from accessing the active site.

Dosage forms of Eflornithine

Creamtopical13.9 %
Creamtopical139 mg/g

Prescription Generics


International Brands



(RS)-2,5-diamino-2-(difluoromethyl)pentanoic acid DFMO


Allergan, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Eflornithine

Eflornithine is indicated in the treatment of facial hirsutism (excessive hair growth).

Toxicity of Eflornithine

In a repeated insult patch test (230 subjects), erythema with edema occurred in 38.9% of subjects treated with eflornithine HCl 13.9% cream and 4.8% of subjects treated with vehicle cream. Challenge applications at previously untested sites following the three-week induction period produced noticeable erythema or greater on only four sites treated with eflornithine HCl 13.9% cream and one vehicle-treated site. The erythema at these sites subsided substantially within 24 hours. In a three-week cumulative irritation study (30 subjects), the mean irritation score for sites treated with eflornithine HCl 13.9% cream was 1.33, compared with 0.76 at vehicle-treated sites and 3.09 at positive-control (sodium lauryl sulphate-treated) sites (p < 0.001 between all three groups).

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Eflornithine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Vaniqa?

Vaniqa prevents chemical action in the hair follicles under the skin, which slows down hair growth when the medicine is applied. Vaniqa cream is used to reduce unwanted facial hair in women, it permanently remove facial hair or prevents hair growth.

Vaniqa Cream is for external use only. Continue to use Vaniqa, even if you do not see immediate results. Reduction of facial hair occurs gradually. Improvement may be observed after 4–8 weeks of treatment, however, some patients may take longer. If there is no improvement after 6 months, treatment should be discontinued. Hair growth can return to pretreatment levels approximately 8 weeks after stopping treatment.

Follow all directions on label and package. Tell each of your health care providers about all your medical conditions, allergies, and all medications you use.

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