Save up -80% on Eletriptan
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Price of Eletriptan
Relpax 20 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Eletriptan volume of distribution
* 138 L
What is Eletriptan
Eletriptan is a second generation triptan drug developed by Pfizer Inc for the treatment of migraine headaches. (Wikipedia)
Eletriptan mechanism of action
Eletriptan binds with high affinity to 5-HT1B, 5-HT1D and 5-HT1F receptors, has modest affinity for 5-HT1A, 5-HT1E, 5-HT2B and 5-HT7 receptors, and little or no affinity for 5-HT2A, 5-HT2C, 5-HT3, 5-HT4, 5-HT5A and 5-HT6 receptors. Eletriptan has no significant affinity or pharmacological activity at adrenergic alpha1, alpha2, or beta; dopaminergic D1 or D2; muscarinic; or opioid receptors. Two theories have been proposed to explain the efficacy of 5-HT receptor agonists in migraine. One theory suggests that activation of 5-HT1 receptors located on intracranial blood vessels, including those on the arteriovenous anastomoses, leads to vasoconstriction, which is correlated with the relief of migraine headache. The other hypothesis suggests that activation of 5-HT1 receptors on sensory nerve endings in the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release.
Dosage forms of Eletriptan
|Tablet, film coated||oral||20 mg/1|
Humans and other mammals
Indication of Eletriptan
For the acute treatment of migraine with or without aura in adults.
Toxicity of Eletriptan
Based on the pharmacology of the 5-HT1B/1D agonists, hypertension or other more serious cardiovascular symptoms could occur on overdose.
Disclaimer: before buying a Eletriptan on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.