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2019 Price of Truvada

$1667.7530 tablets/200 mg
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Emtricitabine volume of distribution

Typical population parameter estimates (interindividual variability) were apparent elimination and intercompartmental clearances of 15.1 liters/h (17.4%) and 5.75 liters/h, respectively, and apparent central and peripheral volumes of distribution of 42.3 liters and 55.4 liters, respectively.

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What is Emtricitabine

Emtricitabine is a nucleoside reverse transcriptase inhibitor (NRTI) for the treatment of HIV infection in adults. Emtricitabine is an analogue of cytidine. The drug works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA.

Emtricitabine mechanism of action

Emtricitabine works by inhibiting reverse transcriptase, the enzyme that copies HIV RNA into new viral DNA. Emtricitabine is a synthetic nucleoside analogue of cytidine. It is phosphorylated by cellular enzymes to form emtricitabine 5′-triphosphate, which is responsible for the inhibition of HIV-1 reverse transcriptase. It competes with the natural substrate deoxycytidine 5′-triphosphate and incorporates into nascent viral DNA, resulting in early chain termination. Therefore emtricitabine inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate deoxycytidine 5′-triphosphate and by its incorporation into viral DNA. By inhibiting HIV-1 reverse transcriptase, emtricitabine can help to lower the amount of HIV, or “viral load”, in a patient’s body and can indirectly increase the number of immune system cells (called T cells or CD4+ T-cells). Both of these changes are associated with healthier immune systems and decreased likelihood of serious illness.

Dosage forms of Emtricitabine

DrugDosageQuantityPrice
Stribild150/150/200/300mg30$1,830.00
Efavirenz/Emtricitabine/Tenofovir600/200/300mg30 Tablet$106.70
Efavirenz/Emtricitabine/Tenofovir600/200/300mg90 Tablet$298.25

Prescription Generics

false

International Brands

Atripla

Synonyms

(-)-(2R,5S)-5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine (-)-2′-Deoxy-5-fluoro-3′-thiacytidine

Manufacturers

A S Medication Solutions

CAS number

143491-57-0

UNII

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Emtricitabine

Indicated, in combination with other antiretroviral agents, for the treatment of HIV-1 infection in adults and for postexposure prophylaxis of HIV infection in health care workers and others exposed occupationally or nonoccupationally via percutaneous injury or mucous membrane or nonintact skin contact with blood, tissues, or other body fluids associated with risk for transmission of the virus.

Toxicity of Emtricitabine

Symptoms of overdose include serious liver problems (hepatotoxicity, with liver enlargement and fat in the liver called steatosis) or a lactic acidosis (buildup of an acid in the blood).

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What is Truvada?

Truvada contains a combination of emtricitabine and tenofovir. Emtricitabine and tenofovir are antiviral drugs that prevent the multiplication of human immunodeficiency virus (human immunodeficiency) cells.

Truvada is used to treat HIV, a virus that can cause Acquired Immunodeficiency Syndrome (AIDS). This medicine is not a medicine for HIV or AIDS, but it can be used to treat HIV infection in adults and children who are at least 12 years old and weigh at least 17 kilograms (37 pounds).

Truvada can be used with safer sex practices to reduce the risk of getting HIV. You must be HIV-negative and adult to use for this purpose. It can not provide protection from disease in every person.

Do not take Truvada if you are also taking other medicines that contain emtricitabine, tenofovir, lamivudine, or adefovir. It is sometimes used to reduce the risk of contracting HIV. You must be HIV negative to use Truvada for this purpose.

Truvada can cause a serious condition called lactic acidosis. Get emergency medical care if you have even mild symptoms, such as muscle pain or weakness, numbness or coldness in your hands and feet, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rhythm, dizziness or feeling very weak or tired.

If you have hepatitis B, you may develop liver symptoms after you stop taking this medicine, even a few months after stopping.