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Enoxaparin volume of distribution
The volume of distribution of enoxaparin, based on anti-factor Xa activity, is 6 liters (in an average patient). The elimination half-life of enoxaparin administered subcutaneously, based on anti-factor Xa activity, is 4.5 hours and is primarily renal.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Enoxaparin
Enoxaparin is a low molecular weight heparin. Enoxaparin is used to prevent and treat deep vein thrombosis or pulmonary embolism, and is given as a subcutaneous injection. Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa. Factor Xa catalyzes the conversion of prothrombin to thrombin, so enoxaparin’s inhibition of this process results in decreased thrombin and ultimately the prevention of fibrin clot formation. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.
Enoxaparin mechanism of action
The mechanism of action of enoxaparin is antithrombin-dependent. It acts mainly by accelerating the rate of the neutralization of certain activated coagulation factors by antithrombin, but other mechanisms may also be involved. The antithrombotic effect of enoxaparin is well correlated to the inhibition of factor Xa. Enoxaparin interacts with Antithrombin III, Prothrombin and Factor X. Enoxaparin binds to and accelerates the activity of antithrombin III. By activating antithrombin III, enoxaparin preferentially potentiates the inhibition of coagulation factors Xa and IIa.
Dosage forms of Enoxaparin
|Lovenox||30mg||10syr Prefilled Syringe||$115.00|
|Lovenox||40mg/0.4mL||10syr Prefilled Syringe||$159.00|
Humans and other mammals
Indication of Enoxaparin
For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Toxicity of Enoxaparin
Mouse, median lethal dose greater than 5000 mg/kg. Another side effect is heparin induced thrombocytopenia (HIT syndrome). HIT is caused by an immunological reaction that makes platelets form clots within the blood vessels, thereby using up coagulation factors.
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What is Lovenox?
Lovenox is an anticoagulant that helps prevent the formation of blood clots. Lovenox is used to treat or prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). DVT can occur after certain types of surgery or in people who suffer from bed due to prolonged illness. Lovenox is also used to prevent complications of blood vessels in people with certain types of angina pectoris (chest pain) or heart attack.
You should not use Lovenox if you have active bleeding, or low platelet count in the blood after testing for the presence of a specific antibody when using Lovenox. Lovenox can cause a very serious blood clot around the spinal cord if you experience spinal bleeding or receive spinal anesthesia (epidural), especially if you have a genetic spinal defect, a history of spinal surgery or repeated spinal retractions, or if you use other drugs that may affect blood coagulation, including blood thinners or NSAIDs (ibuprofen, advil, aleve, etc.). This type of blood clot can lead to prolonged or permanent paralysis. Get emergency medical help if you have symptoms of a spinal cord clot, such as back pain, numbness or muscle weakness in the lower body, or loss of bladder or bowel control.