Save up -80% on Entacapone

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Entacapone

Comtan 200 mg tablet



* price without discount in nearest pharmacy. Price may vary.

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Entacapone volume of distribution

* 20 L

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What is Entacapone

Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson‘s disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor.

Entacapone mechanism of action

The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome.

Dosage forms of Entacapone

Tablet, film coatedoral
Film-coated tabletOral use200 mg
Tabletoral200 mg
Prescription Generics


International Brands



(e)-alpha-Cyano-N,N-diethyl-3,4-dihydroxy-5-nitrocinnamamide Comtan


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Entacapone

Used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson’s Disease who experience the signs and symptoms of end-of-dose “wearing-off”.

Toxicity of Entacapone

Side effect include increase the occurrence of orthostatic hypotension, severe rhabdomyolysis, dyskinesia, hallucinations, hyperkinesia, hypokinesia, dizziness, fatigu,e gastrointestinal effects including abdominal pain constipation diarrhea nausea

RX24 Drugs Disclaimer: before buying a Entacapone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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