Save up -80% on Entacapone
Note: this is a drug discount program, not an insurance plan.
2018 Price of Entacapone
Comtan 200 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Entacapone volume of distribution
* 20 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Entacapone
Entacapone is a selective, reversible catechol-O-methyl transferase (COMT) inhibitor for the treatment of Parkinson‘s disease. It is a member of the class of nitrocatechols. When administered concomittantly with levodopa and a decarboxylase inhibitor (e.g., carbidopa), increased and more sustained plasma levodopa concentrations are reached as compared to the administration of levodopa and a decarboxylase inhibitor.
Entacapone mechanism of action
The mechanism of action of entacapone is believed to be through its ability to inhibit COMT in peripheral tissues, altering the plasma pharmacokinetics of levodopa. When entacapone is given in conjunction with levodopa and an aromatic amino acid decarboxylase inhibitor, such as carbidopa, plasma levels of levodopa are greater and more sustained than after administration of levodopa and an aromatic amino acid decarboxylase inhibitor alone. It is believed that at a given frequency of levodopa administration, these more sustained plasma levels of levodopa result in more constant dopaminergic stimulation in the brain, leading to a greater reduction in the manifestations of parkinsonian syndrome.
Dosage forms of Entacapone
|Tablet, film coated||oral|
|Film-coated tablet||Oral use||200 mg|
Humans and other mammals
Indication of Entacapone
Used as an adjunct to levodopa / carbidopa in the symptomatic treatment of patients with idiopathic Parkinson’s Disease who experience the signs and symptoms of end-of-dose “wearing-off”.
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