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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Inspra

$44.1830 tablets/25 mg
price without discount in nearest pharmacy. Price may vary.

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Eplerenone volume of distribution

Apparent volume of distribution of 43–90 liters, the eplerenone concentration at the moment of the experiment is approximately 1.7 µM.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Eplerenone

Eplerenone, an aldosterone receptor antagonist similar to spironolactone, has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of eplerenone. Eplerenone selectively binds to recombinant human mineralocorticoid receptors relative to its binding to recombinant human glucocorticoid, progesterone and androgen receptors.

Eplerenone mechanism of action

Eplerenone binds to the mineralocorticoid receptor and thereby blocks the binding of aldosterone (component of the renin-angiotensin-aldosterone-system, or RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms.

Dosage forms of Eplerenone

FormRouteStrength
Tabletoral50 mg/1
Tablet, film coatedoral25 mg/1
Tablet, film coatedoral50 mg/1

Prescription Generics

true

International Brands

Eplerenone

Synonyms

Epoxymexrenone Inspra

Manufacturers

American Health Packaging

CAS number

107724-20-9

UNII

6995V82D0B

State

solid

Affected organisms

Humans and other mammals

Indication of Eplerenone

For improvement of survival of stable patients with left ventricular systolic dysfunction (ejection fraction 40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

Toxicity of Eplerenone

The most likely symptoms of human overdosage would be anticipated to be hypotension or hyperkalemia. However, no cases of human overdosage with eplerenone have been reported.

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