Save up -80% on Epoetin Zeta
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2018 Price of Epoetin Zeta
* price without discount in nearest pharmacy. Price may vary.
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Epoetin Zeta volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Epoetin Zeta
The active substance in Epoetin zeta is a recombinant human erythropoietin (rhEPO) of identical primary structure produced in Chinese Hamster Ovary (CHO) cells. The molecular weight of the glycosylated protein is 30.6 kDa according to the Ph. Eur. monograph, 40% of which are carbohydrate structures. The oligosaccharide chains are subject to posttranslational modifications and display heterogeneity to a certain extent. Epoetin zeta is also identical to Epoetin alfa in terms of its amino acid sequence.
Epoetin Zeta mechanism of action
Binding of erythropoietin to the erythropoietin receptor leads to receptor dimerization, which facilitates activation of JAK-STAT signaling pathways within the cytosol. Activated STAT (signal transducers and activators of transcription) proteins are then translocated to the nucleus where they serve as transcription factors which regulate the activation of specific genes involved in cell division or differentiation.
Dosage forms of Epoetin Zeta
|Solution for injection||Subcutaneous or intravenous use||1000 IU/0.3ml|
|Solution for injection||Subcutaneous or intravenous use||10000 IU/1.0ml|
|Solution for injection||Subcutaneous or intravenous use||2000 IU/0.6ml|
1-165-Erythropoietin (human clone B03XA01) glycoform zeta Epoetin zeta
Humans and other mammals
Indication of Epoetin Zeta
For use in the treatment of symptomatic anaemia associated with chronic renal failure (CRF) in adult and paediatric patients. Also for use in the treatment of anaemia and reduction of transfusion requirements in adult patients receiving chemotherapy for solid tumours, malignant lymphoma or multiple myeloma, and at risk of transfusion as assessed by the patient’s general status (e.g. cardiovascular status, pre-existing anaemia at the start of chemotherapy). Also for used to increase the yield of autologous blood from patients in a predonation program. When administered subcutaneously, Epoetin Zeta is equivalent to Epoetin Alfa in terms of clinical effectiveness.
Toxicity of Epoetin Zeta
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