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Ergonovine maleate 100% powder
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Ergonovine volume of distribution
What is Ergonovine
An ergot alkaloid with uterine and vascular smooth muscle contractile properties. (PubChem)
Ergonovine mechanism of action
Ergonovine directly stimulates the uterine muscle to increase force and frequency of contractions. With usual doses, these contractions precede periods of relaxation; with larger doses, basal uterine tone is elevated and these relaxation periods will be decreased. Contraction of the uterine wall around bleeding vessels at the placental site produces hemostasis. Ergonovine also induces cervical contractions. The sensitivity of the uterus to the oxytocic effect is much greater toward the end of pregnancy. The oxytocic actions of ergonovine are greater than its vascular effects. Ergonovine, like other ergot alkaloids, produces arterial vasoconstriction by stimulation of alpha-adrenergic and serotonin receptors and inhibition of endothelial-derived relaxation factor release. It is a less potent vasoconstrictor than ergotamine. As a diagnostic aid (coronary vasospasm), ergonovine causes vasoconstriction of coronary arteries.
Dosage forms of Ergonovine
|Solution||intramuscular; intravenous||.25 mg|
|Solution||intramuscular; intravenous||0.25 mg|
Ergonovine Maleate Injection
(6AR,9R)-7-methyl-4,6,6a,7,8,9-hexahydro-indolo(4,3-fg)quinoline-9-carboxylic acid ((S)-2-hydroxy-1-methyl-ethyl)-amide
Hospira Healthcare Corporation
Humans and other mammals
Indication of Ergonovine
Used to treat postpartum haemorrhage and postabortion haemorrhage in patients with uterine atony.
Toxicity of Ergonovine
The principal symptoms of overdose are convulsions and gangrene. Other symptoms include bradycardia, confusion, diarrhoea, dizziness, dyspnoea, drowsiness, fast and/or weak pulse, miosis, hypercoagulability, loss of consciousness, nausea and vomiting, numbness and coldness of the extremities, pain in the chest, peripheral vasoconstriction, respiratory depression, rise or fall in blood pressure, severe cramping of the uterus, tachycardia, tingling, and unusual thirst.
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