Save up -80% on Eribulin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Halaven
|$1,159.95||1 vial 1mg/2ml|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Eribulin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Eribulin every time. What are you waiting for? Claim your prescription drug card now!
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Eribulin volume of distribution
43 L/m2 to 114 L/m2
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Eribulin
Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of advanced solid tumors.[PMID: 23010853]
Eribulin mechanism of action
Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. Eribulin exerts its effects via a tubulin-based antimitotic mechanism leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.[FDA]
Dosage forms of Eribulin
|Solution for injection||Intravenous use||0.44 mg/ml|
2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2′,3′-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one eribulin mesylate
Indication of Eribulin
For the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic cancer.
Toxicity of Eribulin
Peripheral neuropathy was the most common toxicity leading to discontinuation of eribulin (5 percent).[Richard Pazdur, M.D., director of the FDA’s Division of Oncology Drug Products.]Single doses of 0.75 mg/kg were lethal to rats and two doses of 0.075 mg/kg were lethal to dogs. The no-observed-adverse-effect level (NOAEL) in rats and dogs were 0.015 and 0.0045 mg/kg/day, respectively.
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