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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Eribulin

$

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Eribulin volume of distribution

43 L/m2 to 114 L/m2

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What is Eribulin

Eribulin is a microtubule inhibitor indicated for the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic disease. Eribulin was isolated from the marine sponge Halichondria okadai. Eribulin is also being investigated for use in the treatment of advanced solid tumors.[PMID: 23010853]

Eribulin mechanism of action

Eribulin inhibits the growth phase of microtubules without affecting the shortening phase and sequesters tubulin into nonproductive aggregates. Eribulin exerts its effects via a tubulin-based antimitotic mechanism leading to G2/M cell-cycle block, disruption of mitotic spindles, and, ultimately, apoptotic cell death after prolonged mitotic blockage.[FDA]

Dosage forms of Eribulin

FormRouteStrength
Injectionintravenous.5 mg/mL
Solutionintravenous0.5 mg
Solution for injectionIntravenous use0.44 mg/ml
Prescription Generics

false

International Brands

Halaven

Synonyms

2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy- 26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy- 7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2′,3′-5,6) pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-one eribulin mesylate

Manufacturers

Eisai Inc.

CAS number

253128-41-5

UNII

LR24G6354G

State

liquid

Affected organisms

Indication of Eribulin

For the treatment of patients with metastatic breast cancer who have previously received at least two chemotherapeutic regimens for the treatment of metastatic cancer.

Toxicity of Eribulin

Peripheral neuropathy was the most common toxicity leading to discontinuation of eribulin (5 percent).[Richard Pazdur, M.D., director of the FDA’s Division of Oncology Drug Products.]Single doses of 0.75 mg/kg were lethal to rats and two doses of 0.075 mg/kg were lethal to dogs. The no-observed-adverse-effect level (NOAEL) in rats and dogs were 0.015 and 0.0045 mg/kg/day, respectively.

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