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Price of Ertapenem
Invanz 1 gm vial
* price without discount in nearest pharmacy. Price may vary.
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Ertapenem volume of distribution
* 0.12 liter/kg (adults)
* 0.2 liter/kg (pediatric, 3 months to 12 years)
* 0.16 liter/kg (pediatric patients 13 to 17 years)
What is Ertapenem
Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz reg;. It is structurally very similar to meropenem in that it possess a 1-beta-methyl group. (Wikipedia)
Ertapenem mechanism of action
The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In i Escherichia coli /i , it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases.
Dosage forms of Ertapenem
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||1 g/1|
|Injection, powder, lyophilized, for solution||intravenous||1 g/1|
|Powder for concentrate for solution for infusion||Intravenous use||1 g|
Merck Sharp Dohme Corp.
Enteric bacteria and other eubacteria
Indication of Ertapenem
For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to i Escherichia coli /i , i Clostridium clostridioforme /i , i Eubacterium lentum /i , i Peptostreptococcus /i species, i Bacteroides fragilis /i , i Bacteroides distasonis /i , i Bacteroides ovatus /i , i Bacteroides thetaiotaomicron /i , or i Bacteroides uniformis /i , (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to i Staphylococcus aureus /i (methicillin susceptible isolates only), i Streptococcus agalactiae /i , i Streptococcus pyogenes /i , i Escherichia coli /i , i Klebsiella pneumoniae /i , i Proteus mirabilis /i , i Bacteroides fragilis /i , i Peptostreptococcus /i species, i Porphyromonas asaccharolytica /i , or i Prevotella bivia /i , (3) community acquired pneumonia due to i Streptococcus pneumoniae /i (penicillin susceptible isolates only) including cases with concurrent bacteremia, i Haemophilus influenzae /i (beta-lactamase negative isolates only), or i Moraxella catarrhalis /i , (4) complicated urinary tract infections including pyelonephritis due to i Escherichia coli /i , including cases with concurrent bacteremia, or i Klebsiella pneumoniae /i , (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to i Streptococcus agalactiae /i , i Escherichia coli /i , i Bacteroides fragilis /i , i Porphyromonas asaccharolytica /i , i Peptostreptococcus /i species, or i Prevotella bivia /i .
Toxicity of Ertapenem
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