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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Invanz

$135.761 vial/1g
price without discount in nearest pharmacy. Price may vary.

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Ertapenem volume of distribution

* 0.12 liter/kg (adults) * 0.2 liter/kg (pediatric, 3 months to 12 years) * 0.16 liter/kg (pediatric patients 13 to 17 years)

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What is Ertapenem

Ertapenem is a carbapenem antibiotic marketed by Merck as Invanz reg;. It is structurally very similar to meropenem in that it possess a 1-beta-methyl group. (Wikipedia)

Ertapenem mechanism of action

The bactericidal activity of ertapenem results from the inhibition of cell wall synthesis and is mediated through ertapenem binding to penicillin binding proteins (PBPs). In i Escherichia coli /i , it has strong affinity toward PBPs 1a, 1b, 2, 3, 4 and 5 with preference for PBPs 2 and 3. Ertapenem is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases. Ertapenem is hydrolyzed by metallo-beta-lactamases.

Dosage forms of Ertapenem

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular; intravenous1 g/1
Injection, powder, lyophilized, for solutionintravenous1 g/1
Powder for concentrate for solution for infusionIntravenous use1 g

Prescription Generics

false

International Brands

Invanz

Synonyms

(1R,5S,6S,8R,2’S,4’s)-2-(2-(3-carboxyphenylcarbamoyl)pyrrolidin-4-ylthio)-6-(1-hydroxyethyl)-1-methylcarbapenem-3-carboxylic acid (4R,5S,6S)-3-((3S,5S)-5-((3-Carboxyphenyl)carbamoyl)pyrrolidin-3-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-aza-bicyclo(3.2.0)hept-2-ene-2-carboxylic acid

Manufacturers

Merck Sharp Dohme Corp.

CAS number

153832-46-3

UNII

G32F6EID2H

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Ertapenem

For the treatment the following moderate to severe infections caused by susceptible isolates of the designated microorganisms: (1) complicated intra-abdominal infections due to i Escherichia coli /i , i Clostridium clostridioforme /i , i Eubacterium lentum /i , i Peptostreptococcus /i species, i Bacteroides fragilis /i , i Bacteroides distasonis /i , i Bacteroides ovatus /i , i Bacteroides thetaiotaomicron /i , or i Bacteroides uniformis /i , (2) complicated skin and skin structure infections, including diabetic foot infections without osteomyelitis due to i Staphylococcus aureus /i (methicillin susceptible isolates only), i Streptococcus agalactiae /i , i Streptococcus pyogenes /i , i Escherichia coli /i , i Klebsiella pneumoniae /i , i Proteus mirabilis /i , i Bacteroides fragilis /i , i Peptostreptococcus /i species, i Porphyromonas asaccharolytica /i , or i Prevotella bivia /i , (3) community acquired pneumonia due to i Streptococcus pneumoniae /i (penicillin susceptible isolates only) including cases with concurrent bacteremia, i Haemophilus influenzae /i (beta-lactamase negative isolates only), or i Moraxella catarrhalis /i , (4) complicated urinary tract infections including pyelonephritis due to i Escherichia coli /i , including cases with concurrent bacteremia, or i Klebsiella pneumoniae /i , (5) acute pelvic infections including postpartum endomyometritis, septic abortion and post surgical gynecologic infections due to i Streptococcus agalactiae /i , i Escherichia coli /i , i Bacteroides fragilis /i , i Porphyromonas asaccharolytica /i , i Peptostreptococcus /i species, or i Prevotella bivia /i .

Toxicity of Ertapenem

No specific information is available on the treatment of overdosage with ertapenem. Intentional overdosing of ertapenem is unlikely. Intravenous administration of ertapenem at a dose of 2 g over 30 min or 3 g over 1-2 hr in healthy adult volunteers resulted in an increased incidence of nausea. In clinical trials in adults, inadvertent administration of three 1 g doses of ertapenem in a 24 hour period resulted in diarrhea and transient dizziness in one patient. In pediatric clinical trials, a single intravenous dose of 40 mg/kg up to a maximum of 2 g did not result in toxicity.

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