Save up -80% on Estradiol

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Estrace

$35.211 carton (8 twice-weekly patches) 0.1mg/day
price without discount in nearest pharmacy. Price may vary.

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Estradiol volume of distribution

Approximate dosage proportionality was seen with area under the curve, the terminal half-life was 27.45+/-5.65 minutes, and volume of distribution was very low (0.082+/-0.015 L/kg). Estradiol was well tolerated by all study participants.

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2018 Statistics

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Total savings $4,735,080

What is Estradiol

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Estradiol mechanism of action

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Dosage forms of Estradiol

DrugDosageQuantityPrice
Estrace0.5mg100 Tablet$39.75
Estrace1mg100 Tablet$55.50
Estradiol50mcg8 Patch$44.00
Estradiol100mcg24 Patch$154.00
Climara Patch25mcg12 Patch$105.00
Climara Patch75mcg12 Patch$115.00
Climara Patch100mcg24 Patch$193.00
Estraderm Patch100mcg16 Trandsdermal Patch$68.00
Estrace Vaginal Cream0.01%42.5g Cream$340.00
Femring0.1mg/24h1 Vaginal Ring$508.00
Vagifem Vaginal Tablet10mcg18 Vaginal Tablet$35.95
Evamist1.53mg8.1mL Spray Pump$160.00
Estradiol Transdermal System0.05mg8 Patch$123.00
Oesclim Patch50mcg8 Patch$55.00
Vivelle DOT100mcg24 Transdermal Patches$118.00
Estradiol 17b50mcg24 Transdermal Patches$90.00
Activella0.5/0.1mg84 Tablet$238.00
Natazia3mg3 Tablet$145.00
Divigel1mg84 Gel Sachets$148.00
Minivelle0.05mg8 Patch$173.00
Combipatch0.05/0.14mg24 Patch$158.00

Prescription Generics

false

International Brands

Activella

Synonyms

(17beta)-Estra-1,3,5(10)-triene-3,17-diol 17beta Oestradiol

Manufacturers

Novo Nordisk

CAS number

50-28-2

UNII

4TI98Z838E

State

solid

Affected organisms

Humans and other mammals

Indication of Estradiol

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Toxicity of Estradiol

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

RX24 Drugs Disclaimer: before buying a Estradiol on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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