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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Estrace

$35.211 carton (8 twice-weekly patches) 0.1mg/day
price without discount in nearest pharmacy. Price may vary.

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Estradiol volume of distribution

Approximate dosage proportionality was seen with area under the curve, the terminal half-life was 27.45+/-5.65 minutes, and volume of distribution was very low (0.082+/-0.015 L/kg). Estradiol was well tolerated by all study participants.

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What is Estradiol

Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.

Estradiol mechanism of action

Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

Dosage forms of Estradiol

Estrace0.5mg100 Tablet$39.75
Estrace1mg100 Tablet$55.50
Estradiol50mcg8 Patch$44.00
Estradiol100mcg24 Patch$154.00
Climara Patch25mcg12 Patch$105.00
Climara Patch75mcg12 Patch$115.00
Climara Patch100mcg24 Patch$193.00
Estraderm Patch100mcg16 Trandsdermal Patch$68.00
Estrace Vaginal Cream0.01%42.5g Cream$340.00
Femring0.1mg/24h1 Vaginal Ring$508.00
Vagifem Vaginal Tablet10mcg18 Vaginal Tablet$35.95
Evamist1.53mg8.1mL Spray Pump$160.00
Estradiol Transdermal System0.05mg8 Patch$123.00
Oesclim Patch50mcg8 Patch$55.00
Vivelle DOT100mcg24 Transdermal Patches$118.00
Estradiol 17b50mcg24 Transdermal Patches$90.00
Activella0.5/0.1mg84 Tablet$238.00
Natazia3mg3 Tablet$145.00
Divigel1mg84 Gel Sachets$148.00
Minivelle0.05mg8 Patch$173.00
Combipatch0.05/0.14mg24 Patch$158.00

Prescription Generics


International Brands



(17beta)-Estra-1,3,5(10)-triene-3,17-diol 17beta Oestradiol


Novo Nordisk

CAS number






Affected organisms

Humans and other mammals

Indication of Estradiol

For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).

Toxicity of Estradiol

Can cause nausea and vomiting, and withdrawal bleeding may occur in females.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Estradiol on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Estrace?

Estrace tablets contain estradiol, a form of estrogen. Estradiol is a female sex hormone produced by the ovaries that regulates many processes in the body.

Estrace is used to treat the symptoms of menopause, such as hot flashes and vaginal dryness, burning and irritation. Other uses include the prevention of osteoporosis in postmenopausal women and the replacement of estrogen in women with impaired ovaries or other conditions that cause a lack of natural estrogen in the body. Estrace is also available as a cream.

You should not use Estrace if you have: liver disease, bleeding disorder, unusual vaginal bleeding, a history of hormone-dependent cancer (for example, breast, uterus, ovary, or thyroid cancer), or if you have ever had a heart disease. attack, Stroke or blood clot.

Do not use if you are pregnant. Estrace may increase the risk of developing a condition that may lead to cancer of the uterus. Call your doctor right away if you have unusual vaginal bleeding while using this medication.

Estrace should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase the risk of developing these conditions. Long-term use may also increase the risk of breast cancer or blood clot.