Save up -80% on Estradiol
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Estrace
|$35.21||1 carton (8 twice-weekly patches) 0.1mg/day|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Estradiol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Estradiol every time. What are you waiting for? Claim your prescription drug card now!
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Estradiol volume of distribution
Approximate dosage proportionality was seen with area under the curve, the terminal half-life was 27.45+/-5.65 minutes, and volume of distribution was very low (0.082+/-0.015 L/kg). Estradiol was well tolerated by all study participants.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Estradiol
Generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids. In humans, it is produced primarily by the cyclic ovaries and the placenta. It is also produced by the adipose tissue of men and postmenopausal women. The 17-alpha-isomer of estradiol binds weakly to estrogen receptors (receptors, estrogen) and exhibits little estrogenic activity in estrogen-responsive tissues. Various isomers can be synthesized.
Estradiol mechanism of action
Estradiol enters target cells freely (e.g., female organs, breasts, hypothalamus, pituitary) and interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.
Dosage forms of Estradiol
|Climara Patch||25mcg||12 Patch||$105.00|
|Climara Patch||75mcg||12 Patch||$115.00|
|Climara Patch||100mcg||24 Patch||$193.00|
|Estraderm Patch||100mcg||16 Trandsdermal Patch||$68.00|
|Estrace Vaginal Cream||0.01%||42.5g Cream||$340.00|
|Femring||0.1mg/24h||1 Vaginal Ring||$508.00|
|Vagifem Vaginal Tablet||10mcg||18 Vaginal Tablet||$35.95|
|Evamist||1.53mg||8.1mL Spray Pump||$160.00|
|Estradiol Transdermal System||0.05mg||8 Patch||$123.00|
|Oesclim Patch||50mcg||8 Patch||$55.00|
|Vivelle DOT||100mcg||24 Transdermal Patches||$118.00|
|Estradiol 17b||50mcg||24 Transdermal Patches||$90.00|
|Divigel||1mg||84 Gel Sachets||$148.00|
(17beta)-Estra-1,3,5(10)-triene-3,17-diol 17beta Oestradiol
Humans and other mammals
Indication of Estradiol
For the treatment of urogenital symptoms associated with post-menopausal atrophy of the vagina (such as dryness, burning, pruritus and dyspareunia) and/or the lower urinary tract (urinary urgency and dysuria).
Toxicity of Estradiol
Can cause nausea and vomiting, and withdrawal bleeding may occur in females.
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