Save up -80% on Estramustine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Emcyt
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Emcyt coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Estramustine every time. What are you waiting for? Claim your prescription drug card now!
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Estramustine volume of distribution
The mean volumes of distribution were small, being 43 and 108 ml/kg for the central and peripheral compartments, respectively. The plasma clearance was 64 ml/kg/h, and the half-lives of the two phases were 0.16 and 1.27 h.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Estramustine
A nitrogen mustard linked to estradiol, usually as phosphate; used to treat prostatic neoplasms; also has radiation protective properties.
Estramustine mechanism of action
Estramustine is a derivative of estradiol with a nitrogen mustard moiety. This gives it alkylating properties. In vivo, the nitrogen mustard component is active and can alklyate DNA and other cellular components (such as tubulin components) of rapidly dividing cells. This causes DNA strandbreaks or misscoding events. This leads to apoptosis and cell death. Also, due to the drugs estrogen component, it can bind more selectively to active estrogen receptors.
Dosage forms of Estramustine
17beta-Estradiol 3-(bis(2-chloroethyl)carbamate) 17.-Estradiol 3-(bis(2-chloroethyl)carbamate)
Pfizer Canada Inc
Humans and other mammals
Indication of Estramustine
For the palliative treatment of patients with metastatic and/or progressive carcinoma of the prostate
Toxicity of Estramustine
The primary endpoint was overall survival (OS) with pooled hazard ratios. Secondary endpoints were prostate-specific antigen (PSA) response and grade 3 or 4 toxicity using pooled odds ratios. Stata version 12.0 software was used for statistical analysis.
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