Save up -80% on Estrone

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Estrone

Estrone crystal

$11.76

g

* price without discount in nearest pharmacy. Price may vary.

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Estrone volume of distribution

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What is Estrone

Estrone, one of the major mammalian estrogens, is an aromatized C18 steroid with a 3-hydroxyl group and a 17-ketone. It is produced in vivo from androstenedione or from testosterone via estradiol. It is produced primarily in the ovaries, placenta, and in peripheral tissues (especially adipose tissue) through conversion of adrostenedione. Estrone may be further metabolized to 16-alpha-hydroxyestrone, which may be reduced to estriol by estradiol dehydrogenase.

Estrone mechanism of action

Estrogens enter the cells of responsive tissues (e.g. female organs, breasts, hypothalamus, pituitary) where they interact with estrogen receptors. Hormone-bound estrogen receptors dimerize, translocate to the nucleus of cells and bind to estrogen response elements (ERE) of genes. Binding to ERE alters the transcription rate of affected genes. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) release from the anterior pituitary.

Dosage forms of Estrone

FormRouteStrength
Creamvaginal0.1 %
Suppositoryvaginal.25 mg
Creamvaginal1 mg
Prescription Generics

false

International Brands

Estragyn Vaginal Cream

Synonyms

3-Hydroxy-1,3,5(10)-estratrien-17-one Estrona

Manufacturers

Searchlight Pharma Inc

CAS number

53-16-7

UNII

2DI9HA706A

State

solid

Affected organisms

Humans and other mammals

Indication of Estrone

For management of perimenopausal and postmenopausal symptoms.

Toxicity of Estrone

Symptoms of overdose include nausea and vomiting. Estrogen related side effects include nausea, breast tenderness, fluid retention and edema, headaches and/or migraines, chloasma and poor contact lens fit. Estrogen hormone deficiency is associated with breakthrough bleeding, hypomenorrhea, irritability, depression and menopausal symptoms. Withdrawal bleeds may occur in females.

RX24 Drugs Disclaimer: before buying a Estrone on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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