Save up -80% on Ethacrynic acid

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Edecrin

$181.4430 tablets/25mg
price without discount in nearest pharmacy. Price may vary.

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Ethacrynic acid volume of distribution

Ethacrynic acid is rapidly absorbed from the GI tract. Following oral admin, the diuretic effect occurs within 30 min and reaches a peak in approx 2 hr. The duration of action following oral admin is usually 6-8 hr but may continue up to 12 hr. Following IV admin of ethacrynate sodium, diuresis usually occurs within 5 min, reached a max within 15-30 min, and persists for approx 2 hr. In animals, substantial quantities of ethacrynic acid accumulate only in the liver. The drug does not enter the CSF. It is not known whether ethacrynic acid crosses the placenta or is distributed into milk in humans.

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What is Ethacrynic acid

A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic.

Ethacrynic acid mechanism of action

Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma and extracellular fluid volume; cardiac output also decreases, explaining its antihypertensive action. Eventually, cardiac output returns to normal with an accompanying decrease in peripheral resistance. Its mode of action does not involve carbonic anhydrase inhibition.

Dosage forms of Ethacrynic acid

FormRouteStrength
Tabletoral25 mg/1
Tabletoral25 mg
Tabletoral50 mg

Prescription Generics

false

International Brands

Edecrin

Synonyms

(2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy)acetic acid acide etacrynique

Manufacturers

Avera Mc Kennan Hospital

CAS number

58-54-8

UNII

M5DP350VZV

State

solid

Affected organisms

Humans and other mammals

Indication of Ethacrynic acid

For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.

Toxicity of Ethacrynic acid

Overdosage may lead to excessive diuresis with electrolyte depletion.

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