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Price of Etacrynic acid
Edecrin 25 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Etacrynic acid volume of distribution
What is Etacrynic acid
A compound that inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. This compound has been classified as a loop or high ceiling diuretic. (PubChem)
Etacrynic acid mechanism of action
Ethacrynic acid inhibits symport of sodium, potassium, and chloride primarily in the ascending limb of Henle, but also in the proximal and distal tubules. This pharmacological action results in excretion of these ions, increased urinary output, and reduction in extracellular fluid. Diuretics also lower blood pressure initially by reducing plasma and extracellular fluid volume; cardiac output also decreases, explaining its antihypertensive action. Eventually, cardiac output returns to normal with an accompanying decrease in peripheral resistance. Its mode of action does not involve carbonic anhydrase inhibition.
Dosage forms of Etacrynic acid
Avera Mc Kennan Hospital
Humans and other mammals
Indication of Etacrynic acid
For the treatment of high blood pressure and edema caused by diseases like congestive heart failure, liver failure, and kidney failure.
Toxicity of Etacrynic acid
Overdosage may lead to excessive diuresis with electrolyte depletion.
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