Save up -80% on Ethinyl Estradiol

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of LO Loestrin FE

$144.131 package (28 tablets) 1 mg
price without discount in nearest pharmacy. Price may vary.

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Ethinyl Estradiol volume of distribution

After a wash-out period of one week, the same preparation was administered during a treatment period of three months. After single dose administration, maximum concentrations of CPA in the serum were 15.2 +/- 6.6 ng/ml. Post maximum drug levels declined biphasically with half-lives of 0.8 +/- 0.4 h and 54.0 +/- 26.0 h, respectively. The apparent clearance was calculated to be 3.6 +/- 0.9 ml x min-1 x kg-1 and the volume of distribution (Vz) was 986 +/- 4371. The free fraction of CPA was 3.5 +/- 1.9% and the fractions bound to heat labile proteins and albumin were 4.6 +/- 2.2% and 92.0 +/- 3.5%, respectively. Trough levels of CPA in the serum increased during a treatment cycle, reaching a steady-state around day 16. An about two-fold accumulation of CPA was observed, which was less than expected theoretically. SHBG concentrations in the serum increased by a factor of three during a cycle, without having any effect on the protein binding of CPA. At the end of treatment cycle three, the terminal half-life of CPA had increased to a mean value of 78.6 +/- 16.0 h and the volume of distribution to a value of 1304 +/- 427 1. The apparent clearance showed a small, although significant decrease to a value of 3.0 +/- 0.4 ml x min-1 x kg-1. The observed changes Vz and t 1/2 during the treatment period were attributed to the distribution of CPA into a deep compartment and the slow release of the drug from this compartment.

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What is Ethinyl Estradiol

A semisynthetic alkylated estradiol with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally and is often used as the estrogenic component in oral contraceptives. Ethinyl estradiol is marketed mostly as a combination oral contraceptive under several brand names such as Alesse, Tri-Cyclen, Triphasil, and Yasmin. The FDA label includes a black box warning that states that combination oral contraceptives should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.

Ethinyl Estradiol mechanism of action

Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).

Dosage forms of Ethinyl Estradiol

Brevicon 21 day35mcg/0.5mg6 Packs$76.50
Select 28 day1/35mcg3 packs$63.00
Desogestrel/Ethinyl Estradiol0.15/0.03mg6 Packs$103.00
Drospirenone/Ethinyl Estradiol3mg/20mcg3 Packs$96.00
Marvelon 28 day0.15/0.03mg3 Packs$97.00
Linessa21 day3 Packs$86.00
Yasmin 28 days3/0.03mg3 Packs$83.00
YAZ Birth Control 28 day3mg/20mcg3 Packs$110.00
Nuvaring120/15mcg3 Ring$115.00
Loestrin 21 Day1/20mcg6 Packs$87.00
Ortho 777 Birth Control 21 day0.5/0.035mg;0.75/0.035mg;1/0.035mg3 Packs$59.00
Alesse 28 day0.1/0.02mg3 Packs$92.00
Levonorgestrel/Ethinyl Estradiol0.15/0.03mg3 Tablet$62.50
Ortho Cyclen 21 day0.25/0.035mg6 Packs$105.00
Ortho Tri Cyclen 21 daynoDose3 Packs$120.00
Ortho Tri Cyclen Lo 28 daynoDose3 Packs$98.00
Levlite 21 day0.1/0.02mg3 Packs$98.00
Lessina21 day3 Tablet$85.00
Ortho Evra 21 day200/35mcg3 Patches$41.00
Cyproterone acetate/ethinyl estradiol2mg/0.035mg6 Packages$103.00
Diane 352mg/0.035mg3 Packages$63.00
Demulen 28 day2/0.03mg3 Packs$79.50
Lolo Birth Control1mg/10mcg84 Tablet$131.00
Seasonique0.15/0.03/0.01mg91 Tablet$110.00
Norethindrone Acetate/Ethinyl Estradiol/Ferrous Fumarate1/20mcg3 Packs$275.00

Prescription Generics


International Brands

Minastrin 24 FE


17 alpha-Ethinylestradiol 17 alpha-Ethynylestradiol


Pfizer Canada Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Ethinyl Estradiol

For treatment of moderate to severe vasomotor symptoms associated with the menopause, female hypogonadism, prostatic carcinoma-palliative therapy of advanced disease, breast cancer, as an oral contraceptive, and as emergency contraceptive.

Toxicity of Ethinyl Estradiol

Oral, mouse LD sub 50 /sub : 1737 mg/kg. Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. The FDA label includes a black box warning that states that combination oral contraceptives with ethinyl estradiol should not be used in women over 35 years old who smoke due to the increased risk of serious cardiovascular side effects.

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What is a Lo Loestrin Fe?

Lo Loestrin Fe (ethinyl estradiol, norethindrone and black fumarate) is a combination drug containing female hormones that prevent ovulation (the release of an egg from the ovary). This drug also causes changes in your cervical mucosa and uterus, which complicates the penetration of sperm into the uterus and more difficult for a fertilized egg that attaches to the uterus. Lo Loestrin Fe is used as a contraceptive to prevent pregnancy.

Do not use Lo Loestrin Fe if you are pregnant or have recently had a baby. You should not take Lo Loestrin Fe if you have any of the following conditions: uncontrolled high blood pressure, heart disease, blood clotting problems, circulatory problems, diabetic problems with the eyes or kidneys, unusual vaginal bleeding, liver disease or cancer liver, severe migraine headaches, if you smoke and are over 35 years old, or if you have ever had breast or uterus cancer, jaundice caused by birth control pills, heart attack, stroke or blood clot.

You may have to use backup birth control, such as condoms or spermicide, when you first start using Lo Loestrin Fe or skip a dose. Follow your doctor’s instructions. Lack of pills increases the risk of becoming pregnant. Carefully follow the “missed dose” instructions if you forget to take your Lo Loestrin Fe tablets.

Some drugs can make Lo Loestrin Fe less effective in preventing pregnancy, including antibiotics, drugs for hepatitis C, drugs for HIV/AIDS, drugs for seizures, or barbiturate sedatives. Tell your doctor about all other medicines that you use.