Save up -80% on Ethionamide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Trecator
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Trecator coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ethionamide every time. What are you waiting for? Claim your prescription drug card now!
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Ethionamide volume of distribution
ETA areas under the concentration-versus-time curve (AUCs) increased linearly with increasing oral doses from 250 to 1000 mg. Compared to the population pattern, delayed absorption was seen at least once in 15% of patients. ETA PK parameter estimates were independent of age, weight, height, gender, and creatinine clearance. TB patients appeared to have larger volumes of distribution (3.22 l/kg) and clearance values (1.88 l/h/kg) compared to previously studied healthy volunteers. This resulted in lower AUC values (3.95 mcg h/ml) in the TB patients.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ethionamide
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Ethionamide mechanism of action
Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from iMycobacterium tuberculosis /i, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Dosage forms of Ethionamide
|Tablet, film coated||oral||250 mg/1|
Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.
Indication of Ethionamide
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Toxicity of Ethionamide
Symptoms of overdose include convulsions, nausea, and vomiting.
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