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Price of Ethionamide
Trecator-SC 250 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Ethionamide volume of distribution
* 93.5 L (healthy volunteers)
What is Ethionamide
A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)
Ethionamide mechanism of action
Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from iMycobacterium tuberculosis /i, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.
Dosage forms of Ethionamide
|Tablet, film coated||oral||250 mg/1|
Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.
Indication of Ethionamide
For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.
Toxicity of Ethionamide
Symptoms of overdose include convulsions, nausea, and vomiting.
Disclaimer: before buying a Ethionamide on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.