Save up -80% on Ethionamide

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ethionamide

Trecator-SC 250 mg tablet

$3.21

tablet

* price without discount in nearest pharmacy. Price may vary.

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Ethionamide volume of distribution

* 93.5 L (healthy volunteers)

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What is Ethionamide

A second-line antitubercular agent that inhibits mycolic acid synthesis. It also may be used for treatment of leprosy. (From Smith and Reynard, Textbook of Pharmacology, 1992, p868)

Ethionamide mechanism of action

Ethionamide may be bacteriostatic or bactericidal in action, depending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organism. Ethionamide, like prothionamide and pyrazinamide, is a nicotinic acid derivative related to isoniazid. It is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazid. Isoniazid inhibits the synthesis of mycoloic acids, an essential component of the bacterial cell wall. Specifically isoniazid inhibits InhA, the enoyl reductase from iMycobacterium tuberculosis /i, by forming a covalent adduct with the NAD cofactor. It is the INH-NAD adduct that acts as a slow, tight-binding competitive inhibitor of InhA.

Dosage forms of Ethionamide

FormRouteStrength
Tablet, film coatedoral250 mg/1
Prescription Generics

false

International Brands

Trecator

Synonyms

2-Ethyl-4-thiopyridylamide 2-ethylthioisonicotinamide

Manufacturers

Wyeth Pharmaceuticals Inc., a subsidiary of Pfizer Inc.

CAS number

536-33-4

UNII

OAY8ORS3CQ

State

solid

Affected organisms

Mycobacteria

Indication of Ethionamide

For use in the treatment of pulmonary and extrapulmonary tuberculosis when other antitubercular drugs have failed.

Toxicity of Ethionamide

Symptoms of overdose include convulsions, nausea, and vomiting.

RX24 Drugs Disclaimer: before buying a Ethionamide on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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