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Price of Ethosuximide
Zarontin 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Ethosuximide volume of distribution
What is Ethosuximide
An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures. (PubChem)
Ethosuximide mechanism of action
Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the “low-voltage activated (LVA)” group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Dosage forms of Ethosuximide
|Capsule, liquid filled||oral||250 mg/1|
Versa Pharm Incorporated
Humans and other mammals
Indication of Ethosuximide
For the treatment of petit mal epilepsy.
Toxicity of Ethosuximide
Acute overdoses may produce nausea, vomiting, and CNS depression including coma with respiratory depression.
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