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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Toposar

$491.0616 capsules/50 mg
price without discount in nearest pharmacy. Price may vary.

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Etoposide volume of distribution

The disposition of etoposide is a biphasic process with a distribution half-life of 1.5 hours. It does not cross into cerebrospinal fluid well. Volume of distribution, steady state = 18 – 29 L.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Etoposide

A semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.

Etoposide mechanism of action

Etoposide inhibits DNA topoisomerase II, thereby inhibiting DNA re-ligation. This causes critical errors in DNA synthesis at the premitotic stage of cell division and can lead to apoptosis of the cancer cell. Etoposide is cell cycle dependent and phase specific, affecting mainly the S and G2 phases of cell division. Inhibition of the topoisomerase II alpha isoform results in the anti-tumour activity of etoposide. The drug is also capable of inhibiting the beta isoform but inhibition of this target is not associated with the anti-tumour activity. It is instead associated with the carcinogenic effect.

Dosage forms of Etoposide

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous100 mg/1
Capsuleoral50 mg/1
Injectionintravenous20 mg/mL

Prescription Generics

false

International Brands

Dom-etoposide

Synonyms

(-)-Etoposide 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

Manufacturers

Dominion Pharmacal

CAS number

33419-42-0

UNII

6PLQ3CP4P3

State

solid

Affected organisms

Humans and other mammals

Indication of Etoposide

For use in combination with other chemotherapeutic agents in the treatment of refractory testicular tumors and as first line treatment in patients with small cell lung cancer. Also used to treat other malignancies such as lymphoma, non-lymphocytic leukemia, and glioblastoma multiforme.

Toxicity of Etoposide

Side effects include alopecia, constipation, diarrhea, nausea and vomiting and secondary malignancies (leukemia).

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