Save up -80% on Everolimus

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

Pharmacists and Patients support.

2018 Price of Everolimus

Vesicare 10 mg tablet

$6.98

tablet

* price without discount in nearest pharmacy. Price may vary.

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We offer free Everolimus coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Everolimus every time. What are you waiting for? Claim your prescription drug card now!

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Everolimus volume of distribution

The blood-to-plasma ratio of everolimus is 17% to 73%.

About RX24Drugs

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What is Everolimus

Everolimus is a derivative of Rapamycin (sirolimus), and works similarly to Rapamycin as an mTOR (mammalian target of rapamycin) inhibitor. It is currently used as an immunosuppressant to prevent rejection of organ transplants. In a similar fashion to other mTOR inhibitors Everolimus’ effect is solely on the mTORC1 protein and not on the mTORC2 protein.

Everolimus mechanism of action

Everolimus is a mTOR inhibitor that binds with high affinity to the FK506 binding protein-12 (FKBP-12), thereby forming a drug complex that inhibits the activation of mTOR. This inhibition reduces the activity of effectors downstream, which leads to a blockage in the progression of cells from G1 into S phase, and subsequently inducing cell growth arrest and apoptosis. Everolimus also inhibits the expression of hypoxia-inducible factor, leading to a decrease in the expression of vascular endothelial growth factor. The result of everolimus inhibition of mTOR is a reduction in cell proliferation, angiogenesis, and glucose uptake.

Dosage forms of Everolimus

DrugDosageQuantityPrice
Zortress0.25mg60 Tablet$406.00
Zortress0.75mg60 Tablet$1,226.00
Prescription Generics

false

International Brands

Afinitor

Synonyms

40-O-(2-hydroxyethyl)-rapamycin

Manufacturers

Novartis Pharmaceuticals Corporation

CAS number

159351-69-6

UNII

9HW64Q8G6G

State

solid

Affected organisms

Humans and other mammals

Indication of Everolimus

Everolimus is indicated for the treatment of postmenopausal women with advanced hormone receptor-positive, HER2-negative breast cancer (advanced HR+ BC) in combination with exemestane, after failure of treatment with letrozole or anastrozole. Indicated for the treatment of adult patients with progressive neuroendocrine tumors of pancreatic origin (PNET) with unresectable, locally advanced or metastatic disease. Indicated for the treatment of adult patients with advanced renal cell carcinoma (RCC) after failure of treatment with sunitinib or sorafenib. Indicated for the treatment of adult patients with renal angiomyolipoma and tuberous sclerosis complex (TSC), not requiring immediate surgery. Indicated in pediatric and adult patients with tuberous sclerosis complex (TSC) for the treatment of subependymal giant cell astrocytoma (SEGA) that requires therapeutic intervention but cannot be curatively resected.

Toxicity of Everolimus

IC50 of 0.63 nM.

RX24 Drugs Disclaimer: before buying a Everolimus on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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