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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Exemestane

Aromasin 25 mg tablet

$13.77tablet
price without discount in nearest pharmacy. Price may vary.

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2018 Statistics

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Discount Cards 16,000+

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What is Exemestane

Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation.

Exemestane mechanism of action

Breast cancer cell growth may be estrogen-dependent. Aromatase (exemestane) is the principal enzyme that converts androgens to estrogens both in pre- and postmenopausal women. While the main source of estrogen (primarily estradiol) is the ovary in premenopausal women, the principal source of circulating estrogens in postmenopausal women is from conversion of adrenal and ovarian androgens (androstenedione and testosterone) to estrogens (estrone and estradiol) by the aromatase enzyme in peripheral tissues. Estrogen deprivation through aromatase inhibition is an effective and selective treatment for some postmenopausal patients with hormone-dependent breast cancer. Exemestane is an irreversible, steroidal aromatase inactivator, structurally related to the natural substrate androstenedione. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation, an effect also known as “suicide inhibition”. Exemestane significantly lowers circulating estrogen concentrations in postmenopausal women, but has no detectable effect on the adrenal biosynthesis of corticosteroids or aldosterone. This reduction in serum and tumor concentrations of estrogen delays tumor growth and disease progression. Exemestane has no effect on other enzymes involved in the steroidogenic pathway up to a concentration at least 600 times higher than that inhibiting the aromatase enzyme.

Dosage forms of Exemestane

DrugDosageQuantityPrice
Aromasin25mg90 Tablet$570.00
Exemestane25mg30 Tablet$124.00

Prescription Generics

false

International Brands

Act Exemestane

Synonyms

6-Methyleneandrosta-1,4-diene-3,17-dione Exemestane

Manufacturers

Actavis Pharma Company

CAS number

107868-30-4

UNII

NY22HMQ4BX

State

solid

Affected organisms

Humans and other mammals

Indication of Exemestane

For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.

Toxicity of Exemestane

Convulsions

RX24 Drugs Disclaimer: before buying a Exemestane on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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