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Price of Famciclovir
Famciclovir 125 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Famciclovir volume of distribution
* 1.080.17 L/kg (healthy male subjects following a single intravenous dose of penciclovir at 400 mg administered as a 1-hour intravenous infusion)
What is Famciclovir
Famciclovir is a guanine analogue antiviral drug used for the treatment of various herpes virus infections, most commonly for herpes zoster (shingles). It is a prodrug form of penciclovir with improved oral bioavailability. Famciclovir is marketed under the trade name Famvir (Novartis).
Famciclovir mechanism of action
Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV). In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases. In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.
Dosage forms of Famciclovir
Actavis Pharma Company
Human Herpes Virus
Indication of Famciclovir
For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.
Toxicity of Famciclovir
Symptoms of overdose include constipation, diarrhea, dizziness, fatigue, fever, headache, nausea, and vomiting.
Disclaimer: before buying a Famciclovir on prescription, consult your health care provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.