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Price of Febuxostat
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Febuxostat volume of distribution
The mean apparent steady state volume of distribution (Vss/F) of febuxostat was approximately 50 L (CV ~40%)
What is Febuxostat
Febuxostat is a xanathine oxidase (XO) inhibitor indicated in patients with gout suffering from hyperuricemia and is used in its chronic management. Febuxostat is not recommended for the treatment of asymptomatic hyperuricemia. Febuxostat is marketed under the trade name Uloric by Takeda Pharmaceuticals America, Inc., and was approved by the FDA in February 2009.
Febuxostat mechanism of action
Febuxostat, a xanthine oxidase inhibitor, achieves its therapeutic effect by decreasing serum uric acid. Febuxostat is not expected to inhibit other enzymes involved in purine and pyrimidine synthesis and metabolism at therapeutic concentrations.
Dosage forms of Febuxostat
|Film-coated tablet||Oral use||120 mg|
|Film-coated tablet||Oral use||80 mg|
|Tablet, film coated||oral||40 mg/1|
2-(3-cyano-4-isobutoxyphenyl)-4-methyl- 1,3-thiazole-5-carboxylic acid
Ranbaxy Pharmaceuticals Inc.
Humans and other mammals
Indication of Febuxostat
For the treatment of hyperuricemia in patients with gout.
Toxicity of Febuxostat
The FDA adverse event reporting system database, AERS, indicated potential signals of febuxostat-associated cardiovascular thromboembolic events. AERS is not capable of establishing the causal link and detecting the true frequency of an adverse event associated with a drug. The positive IC value found in this study merits continued surveillance and assessment of cardiovascular thromboembolic events associated with Febuxostat.
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