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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Plendil

$10.0230 tablets/10mg
price without discount in nearest pharmacy. Price may vary.

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Felodipine volume of distribution

The volume of distribution of felodipine is about 10 L/kg, implying that less than 1% of the amount of drug in the body is localised in the blood. Felodipine is more than 99% bound to plasma proteins. Mean total clearance from the blood is 1 to 1.5 L/min and, therefore, felodipine is considered a high clearance drug.

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What is Felodipine

Felodipine is a long-acting 1,4-dihydropyridine calcium channel blocker (CCB)b. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, felodipine prevents calcium-dependent myocyte contraction and vasoconstriction. Felodipine is the most potent CCB in use and is unique in that it exhibits fluorescent activity. In addition to binding to L-type calcium channels, felodipine binds to a number of calcium-binding proteins, exhibits competitive antagonism of the mineralcorticoid receptor, inhibits the activity of calmodulin-dependent cyclic nucleotide phosphodiesterase, and blocks calcium influx through voltage-gated T-type calcium channels. Felodipine is used to treat mild to moderate essential hypertension.

Felodipine mechanism of action

Felodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through voltage-gated L-type calcium channels. It reversibly competes against nitrendipine and other DHP CCBs for DHP binding sites in vascular smooth muscle and cultured rabbit atrial cells. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of felodipine result in an overall decrease in blood pressure. Felodipine may be used to treat mild to moderate essential hypertension.

Dosage forms of Felodipine

DrugDosageQuantityPrice
Renedil2.5mg30 SA tablet$47.50
Renedil5mg30 SA tablet$52.50
Renedil10mg30 SA tablet$65.00
Plendil2.5mg100 Sustained Release Tablet$88.00
Plendil5mg100 Sustained Release Tablet$120.00
Plendil10mg84 Sustained Release Tablet$97.00
Felodipine5mg84 SR Tablet$59.00
Felodipine10mg84 Sustained-Release Tablet$79.00

Prescription Generics

false

International Brands

Altace Plus Felodipine 2.5mg + 2.5mg

Synonyms

(+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate

Manufacturers

Sanofi Aventis Canada Inc

CAS number

72509-76-3

UNII

OL961R6O2C

State

solid

Affected organisms

Humans and other mammals

Indication of Felodipine

For the treatment of mild to moderate essential hypertension.

Toxicity of Felodipine

Symptoms of overdose include excessive peripheral vasodilation with marked hypotension and possibly bradycardia. Oral rat LD sub 50 /sub is 1050 mg/kg.

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