Save up -80% on Filgrastim

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Filgrastim

Neupogen 300 mcg/ml vial

$286.04vial
price without discount in nearest pharmacy. Price may vary.

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Filgrastim volume of distribution

Vd, healthy subjects and cancer patients = 150 mL/kg

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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Filgrastim

Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology using a strain of E. coli. It is marketed as the brand name Neupogen by Amgen. Chemically, it consists of 175 amino acid residues. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E coli. Tbo-filgrastim, which is marketed by Sicor Biotech and FDA approved on August 29, 2012, contains the same active ingredient as Neupogen and is biologically similar, but it is formulated to be short-acting. On March 6, 2015, the FDA approved the biosimilar Zarxio (filgrastim-sndz) and is indicated for use in the same conditions as Neupogen. Zarxio is marketed by Sandoz.

Filgrastim mechanism of action

Filgrastim binds to the G-CSF receptor and stimulates the production of neutrophils in the bone marrow. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase

Dosage forms of Filgrastim

FormRouteStrength
Solution for injection/infusionSubcutaneous or intravenous use30 MU/0.5ml
Solution for injection/infusionSubcutaneous or intravenous use48 MU/0.5ml
Solution for injection or infusionSubcutaneous or intravenous use30 MIU

Prescription Generics

false

International Brands

Granix

Synonyms

G-CSF Granulocyte Colony Stimulating Factor

Manufacturers

Cephalon, Inc.

CAS number

121181-53-1

UNII

PVI5M0M1GW

State

liquid

Affected organisms

Humans and other mammals

Indication of Filgrastim

Filgrastim is used in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. It is also used in cancer patients receiving bone marrow transplant. In general, filgrastim increases neutrophil counts in order to decrease the risk of infection or duration of neutropenia in the aforementioned patient populations. Infection and neutropenia are adverse events associated with chemotherapy. Furthermore, filgrastim is also indicated for patients with severe chronic neutropenia. It mobilizes hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis to allow for a more rapid engraftment. Tbo-filgrastim has a narrower indication profile than Neupogen – it is a leukocyte growth factor indicated for the reduction in the duration of severe neutropenia in patients with non-myeloid malignancies.

Toxicity of Filgrastim

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Filgrastim on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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