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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Flibanserin

$

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Flibanserin volume of distribution

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What is Flibanserin

Flibanserin is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals. Flibanserin’s mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.

Flibanserin mechanism of action

Flibansetrin has high affinity for serotonin receptors in the brain: it acts as an agonist on 5-HT1A and an antagonist on 5-HT2A. In vivo, flibanserin binds equally to 5-HT1A and 5-HT2A receptors. However, under higher levels of brain 5-HT (i.e., under stress), flibanserin may occupy 5-HT2A receptors in higher proportion than 5-HT(1A) receptors. It may also moderately antagonize D4 (dopamine) receptors and 5-HT2B and 5-HTB2C. Its action on neurotransmitter receptors may contribute to reduction in serotonin levels and increase in dopamine and norepinephrine levels, all of which may play part in reward processing.

Dosage forms of Flibanserin

FormRouteStrength
Tablet, film coatedoral100 mg/1
Prescription Generics

false

International Brands

Addyi

Synonyms

BIMT-17 BIMT-17-BS

Manufacturers

Sprout Pharmaceuticals, Inc.

CAS number

167933-07-5

UNII

37JK4STR6Z

State

solid

Affected organisms

Humans and other mammals

Indication of Flibanserin

For the treatment of hypoactive sexual desire disorder (HSDD) in premenopausal women.

Toxicity of Flibanserin

RX24 Drugs Disclaimer: before buying a Flibanserin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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