Save up -80% on Floxuridine

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Floxuridine

Fudr 500 mg vial

$121.06vial
price without discount in nearest pharmacy. Price may vary.

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We offer free Floxuridine coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Floxuridine every time. What are you waiting for? Claim your prescription drug card now!

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Floxuridine volume of distribution

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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Floxuridine

An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.

Floxuridine mechanism of action

Floxuridine is rapidly catabolized to 5-fluorouracil, which is the active form of the drug. The primary effect is interference with DNA synthesis and to a lesser extent, inhibition of RNA formation through the drug’s incorporation into RNA, thus leading to the production of fraudulent RNA. Fluorouracil also inhibits uracil riboside phophorylase, which prevents the utilization of preformed uracil in RNA synthesis. As well, the monophosphate of floxuridine, 5-fluoro-2′-deoxyuridine-5′-phosphate (FUDR-MP) inhibits the enzyme thymidylate synthetase. This leads to the inhibition of methylation of deoxyuridylic acid to thymidylic acid, thus interfering with DNA synthesis.

Dosage forms of Floxuridine

FormRouteStrength
Injection, powder, lyophilized, for solutionintra-arterial500 mg/5mL

Prescription Generics

true

International Brands

Floxuridine

Synonyms

1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil 1-beta-D-2′-Deoxyribofuranosyl-5-flurouracil

Manufacturers

APP Pharmaceuticals, LLC

CAS number

50-91-9

UNII

039LU44I5M

State

solid

Affected organisms

Humans and other mammals

Indication of Floxuridine

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion).

Toxicity of Floxuridine

Oral, rat LD sub 50 /sub : 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Floxuridine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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