Save up -80% on Flucytosine
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Ancobon
|price without discount in nearest pharmacy. Price may vary.|
We offer free Ancobon coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Flucytosine every time. What are you waiting for? Claim your prescription drug card now!
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Flucytosine volume of distribution
The drug is widely distributed throughout the body; it attains a concentration in cerebrospinal fluid approximately 65% to 90% that of the plasma. Flucytosine has a half-life of 3 to 6 hours and is excreted unchanged in the urine.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Flucytosine
A fluorinated cytosine analog that is used as an antifungal agent.
Flucytosine mechanism of action
Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.
Dosage forms of Flucytosine
Yeast and other fungi
Indication of Flucytosine
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
Toxicity of Flucytosine
Oral, rat: LD sub50 /sub = 15 gm/kg.
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