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Price of Flucytosine
Ancobon 250 mg capsule
* price without discount in nearest pharmacy. Price may vary.
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Flucytosine volume of distribution
What is Flucytosine
A fluorinated cytosine analog that is used as an antifungal agent. (PubChem)
Flucytosine mechanism of action
Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.
Dosage forms of Flucytosine
Yeast and other fungi
Indication of Flucytosine
For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).
Toxicity of Flucytosine
Oral, rat: LD sub50 /sub = 15 gm/kg.
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