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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Flucytosine

Ancobon 250 mg capsule



* price without discount in nearest pharmacy. Price may vary.

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Flucytosine volume of distribution

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What is Flucytosine

A fluorinated cytosine analog that is used as an antifungal agent.

Flucytosine mechanism of action

Although the exact mode of action is unknown, it has been proposed that flucytosine acts directly on fungal organisms by competitive inhibition of purine and pyrimidine uptake and indirectly by intracellular metabolism to 5-fluorouracil. Flucytosine enters the fungal cell via cytosine permease; thus, flucytosine is metabolized to 5-fluorouracil within fungal organisms. The 5-fluorouracil is extensively incorporated into fungal RNA and inhibits synthesis of both DNA and RNA. The result is unbalanced growth and death of the fungal organism. It also appears to be an inhibitor of fungal thymidylate synthase.

Dosage forms of Flucytosine

Capsuleoral250 mg/1
Capsuleoral500 mg/1
Prescription Generics


International Brands



5-FC 5-Fluorocystosine


Cardinal Health

CAS number






Affected organisms

Yeast and other fungi

Indication of Flucytosine

For the treatment (in combination with amphotericin B) of serious infections caused by susceptible strains of Candida (septicemia, endocarditis and urinary system infections) and/or Cryptococcus (meningitis and pulmonary infections).

Toxicity of Flucytosine

Oral, rat: LD sub50 /sub = 15 gm/kg.

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