Save up -80% on Fluorouracil
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2018 Price of Fluorouracil
* price without discount in nearest pharmacy. Price may vary.
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Fluorouracil volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Fluorouracil
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the thymidylate synthetase conversion of deoxyuridylic acid to thymidylic acid.
Fluorouracil mechanism of action
The precise mechanism of action has not been fully determined, but the main mechanism of fluorouracil is thought to be the binding of the deoxyribonucleotide of the drug (FdUMP) and the folate cofactor, N510-methylenetetrahydrofolate, to thymidylate synthase (TS) to form a covalently bound ternary complex. This results in the inhibition of the formation of thymidylate from uracil, which leads to the inhibition of DNA and RNA synthesis and cell death. Fluorouracil can also be incorporated into RNA in place of uridine triphosphate (UTP), producing a fraudulent RNA and interfering with RNA processing and protein synthesis.
Dosage forms of Fluorouracil
|Efudex Cream||5%||40g Cream||$71.00|
Cipher Pharmaceuticals Inc
Humans and other mammals
Indication of Fluorouracil
For the topical treatment of multiple actinic or solar keratoses. In the 5% strength it is also useful in the treatment of superficial basal cell carcinomas when conventional methods are impractical, such as with multiple lesions or difficult treatment sites. Fluorouracil injection is indicated in the palliative management of some types of cancer, including colon, esophageal, gastric, rectum, breast, biliary tract, stomach, head and neck, cervical, pancreas, renal cell, and carcinoid.
Toxicity of Fluorouracil
LD sub50 /sub=230mg/kg (orally in mice)
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