Save up -80% on Flurbiprofen

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Flurbiprofen

Flurbiprofen 100 mg tablet

$1.08

tablet

* price without discount in nearest pharmacy. Price may vary.

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Flurbiprofen volume of distribution

* 14 L (Normal Healthy Adults) * 12 L (Geriatric Arthritis Patients) * 10 L (End Stage Renal Disease Patients) * 14 L (Alcoholic Cirrhosis Patients) * 0.12 L/kg

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What is Flurbiprofen

Flurbiprofen, a propionic acid derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with antipyretic and analgesic activity. Oral formulations of flurbiprofen may be used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis and anklylosing spondylitis. Flurbiprofen may also be used topically prior to ocular surgery to prevent or reduce intraoperative miosis. Flurbiprofen is structurally and pharmacologically related to fenoprofen, ibuprofen, and ketoprofen.

Flurbiprofen mechanism of action

Similar to other NSAIAs, the anti-inflammatory effect of flurbiprofen occurs via reversible inhibition of cyclooxygenase (COX), the enzyme responsible for the conversion of arachidonic acid to prostaglandin G2 (PGG2) and PGG2 to prostaglandin H2 (PGH2) in the prostaglandin synthesis pathway. This effectively decreases the concentration of prostaglandins involved in inflammation, pain, swelling and fever. Flurbiprofen is a non-selective COX inhibitor and inhibits the activity of both COX-1 and -2. It is also one of the most potent NSAIAs in terms of prostaglandin inhibitory activity.

Dosage forms of Flurbiprofen

FormRouteStrength
Patchtopical33 mg/51
Tabletoral100 mg
Tabletoral50 mg
Prescription Generics

false

International Brands

Ansaid Tablets 100 mg

Synonyms

(+-)-2-Fluoro-alpha-methyl-4-biphenylacetic acid 2-(2-Fluorobiphenyl-4-yl)propanoic acid

Manufacturers

Pfizer Canada Inc

CAS number

5104-49-4

UNII

5GRO578KLP

State

solid

Affected organisms

Humans and other mammals

Indication of Flurbiprofen

Flurbiprofen tablets are indicated for the acute or long-term symptomatic treatment of rheumatoid arthritis, osteorarthritis and anklosing spondylitis. It may also be used to treat pain associated with dysmenorrhea and mild to moderate pain accompanied by inflammation (e.g. bursitis, tendonitis, soft tissue trauma). Topical ophthalmic formulations may be used pre-operatively to prevent intraoperative miosis.

Toxicity of Flurbiprofen

LD sub50 /sub=10 mg/kg (orally in dogs). pSelective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of flurbiprofen. Flurbiprofen may increase blood pressure and/or cause fluid retention and edema. Use caution in patients with fluid retention or heart failure. Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Anaphylactoid and serious skin reactions (e.g. exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis) may occur. Common adverse events include abdominal pain, constipation, diarrhea, dyspepsia, flatulence, GI bleeding, GI perforation, nausea, peptic ulcer, vomiting, renal function abnormalities, anemia, dizziness, edema, liver function test abnormalities, headache, prolonged bleeding time, pruritus, rash, tinnitus. Although rarely documented in the case of flurbiprofen, oral propionic acid derivatives have been associated with a relatively high frequency of allergic reactions.

RX24 Drugs Disclaimer: before buying a Flurbiprofen on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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