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Price of Fluticasone Propionate
Flovent Diskus 500 mcg/dose Metered Inhalation Powder
* price without discount in nearest pharmacy. Price may vary.
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Fluticasone Propionate volume of distribution
IV administration = 4.2 L/kg
What is Fluticasone Propionate
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the treatment of asthma. Fluticasone proprionate is marketed under several different brand names such as Flonase. Fluticasone propionate is also available as a combination product of azelastine hydrochloride and fluticasone propionate called Dymista. Dymista is indicated in patients over 12 years old for symptomatic relief of seasonal allergic rhinitis.
Fluticasone Propionate mechanism of action
Binds to the glucocorticoid receptor. Unbound corticosteroids cross the membranes of cells such as mast cells and eosinophils, binding with high affinity to glucocorticoid receptors (GR). The results include alteration of transcription and protein synthesis, a decreased release of leukocytic acid hydrolases, reduction in fibroblast proliferation, prevention of macrophage accumulation at inflamed sites, reduction of collagen deposition, interference with leukocyte adhesion to the capillary wall, reduction of capillary membrane permeability and subsequent edema, reduction of complement components, inhibition of histamine and kinin release, and interference with the formation of scar tissue. In the management of asthma, the glucocorticoid receptor complexes down-regulates proinflammatory mediators such as interleukin-(IL)-1, 3, and 5, and up-regulates anti-inflammatory mediators such as IkappaB (inhibitory molecule for nuclear factor kappaB1), IL-10, and IL-12. The antiinflammatory actions of corticosteroids are also thought to involve inhibition of cytosolic phospholipase A2 (through activation of lipocortin-1 (annexin)) which controls the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
Dosage forms of Fluticasone Propionate
|Aerosol, metered dose||inhalation|
|Powder||oral; respiratory (inhalation)|
24 Hour Allergy Nasal
Humans and other mammals
Indication of Fluticasone Propionate
Fluticasone propionate, a medium-potency synthetic corticosteroid, is used topically to relieve inflammatory and pruritic symptoms of dermatoses and psoriasis, intranasally to manage symptoms of allergic and non-allergic rhinitis, and orally for the maintenance treatment of asthma as prophylactic therapy and for patients requiring oral corticosteroid therapy for asthma.
Toxicity of Fluticasone Propionate
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