Save Money on Fondaparinux

Arixtra Coupon 2020

BIN: 015558PCN: HTGRP: DDN6600Holder: DDN6600
Note: this is a drug discount program, not an insurance plan.

Arixtra Price with Coupon

$123.1360 tablets/1 mg
Note: Cost of Arixtra with RX24 drugs coupon in nearest pharmacy, it may vary.
Drug Generics:Fondaparinux
Fondaparinux Brands:Arixtra
Arixtra Manufacturer:GSK

Get Fondaparinux with Discount in US Pharmacies

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We offer free Fondaparinux coupon with discount that may help you save up to 80% off the retail price in your local pharmacy. Just print a Arixtra coupon! It’s ready to use and never expire like a co-pay. Present your RX24 drug savings card in most local pharmacies to get a discount on Arixtra every time. What are you waiting for? Claim your Fondaparinux drug card now!

Time needed: 3 minutes.

How to use RX24 Arixtra Savings Coupon

  1. Get Your RX Coupon

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  2. Print RX24 Coupon

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  3. Show it to Pharmacist

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  4. Save Money Each Time

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What is Fondaparinux?

Fondaparinux (Arixtra) is a synthetic pentasaccharide anticoagulant. Apart from the O-methyl group at the reducing end of the molecule, the identity and sequence of the five monomeric sugar units contained in fondaparinux is identical to a sequence of five monomeric sugar units that can be isolated after either chemical or enzymatic cleavage of the polymeric glycosaminoglycan heparin and heparan sulfate (HS). This monomeric sequence in heparin and HS is thought to form the high affinity binding site for the natural anti-coagulant factor, antithrombin III (ATIII). Binding of heparin/HS to ATIII has been shown to increase the anti-coagulant activity of antithrombin III 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold. Fondaparinux may be used: to prevent venous thromboembolism in patients who have undergone orthopedic surgery of the lower limbs (e.g. hip fracture, hip replacement and knee surgery); to prevent VTE in patients undergoing abdominal surgery who are are at high risk of thromboembolic complications; in the treatment of deep vein thrombosis (DVT) and pumonary embolism (PE); in the management of unstable angina (UA) and non-ST segment elevation myocardial infarction (NSTEMI); and in the management of ST segment elevation myocardial infarction (STEMI).

Fondaparinux Indication

Approved for: (1) prophylaxis of VTE for up to one month post surgery in patients undergoing orthopedic surgery of the lower limbs such as hip fracture, hip replacement and knee surgery; (2) prophylaxis of VTE patients undergoing abdominal surgery who are at high risk of thromboembolic complications (e.g. patients undergoing abdominal cancer surgery); (3) treatment of acute DVT and PE; (4) management of UA and NSTEMI for the prevention of death and subsequent myocardial infarction (MI); and (5) management of STEMI for the prevention of death and myocardial reinfarction in patients who are managed with thrombolytics or who are initially to receive no form of reperfusion therapy. Fondaparinux should not be used as the sole anticoagulant during percutaneous coronary intervention (PCI) due to an increased risk of guiding catheter thrombosis.

Fondaparinux Mechanism of Action

The antithrombotic activity of fondaparinux is the result of ATIII-mediated selective inhibition of Factor Xa. By selectively binding to ATIII, Fondaparinux potentiates (about 300 times) the neutralization of Factor Xa by ATIII. Neutralization of Factor Xa interrupts the blood coagulation cascade and thus inhibits thrombin formation and thrombus development. It is thought that fondaparinux is unlikely to induce thrombocytopenia via a heparin-induced thrombocytopenia (HIT)-like mechanism given its chemical structure (PMID 19825921). As a result, fondaparinux has been used as an alternative anticoagulant in heparin-induced thrombocytopenia (HIT) patients (PMID 19737996, 19432027, 18217156). However, it is important to note that rare cases of HIT have been reported in patients treated with fondaparinux (PMID 20351685, 20351686).

Fondaparinux Volume of Distribution

Fondaparinux sodium administered by subcutaneous injection is rapidly and completely absorbed (absolute bioavailability is 100%). Following a single subcutaneous dose of fondaparinux sodium 2.5 mg in young male subjects, Cmax of 0.34 mg/L is reached in approximately 2 hours.

Fondaparinux Dosage Forms
DrugDosageQuantityPrice
Arixtra1.5mg/0.3mL10syr Syringe$225.00
Arixtra2.5mg/0.5mL10syr Syringe$225.00
Arixtra5mg/0.4mL10syr Syringe$315.00
Arixtra7.5mg/0.6mL10syr Syringe$315.00
Arixtra10mg/0.8mL10syr Syringe$315.00

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RX24 Disclaimer: consult your healthcare provider before buying a Fondaparinux on prescription or using a Arixtra manufacturer discount coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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