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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Monopril

$13.4530 tablets/40mg
price without discount in nearest pharmacy. Price may vary.

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Fosinopril volume of distribution

Mean maximum concentration (Cmax), clearance (CL), volume of distribution at steady-state (Vss), mean residence time (MRTiv), and t1/2 values after IV administration of 14C-fosinoprilat were 2,042, 11.3 ml.min-1, 11.0 l, 16.3 h and 28.3 h, respectively.

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What is Fosinopril

Fosinopril is a phosphinic acid-containing ester prodrug that belongs to the angiotensin-converting enzyme (ACE) inhibitor class of medications. It is rapidly hydrolyzed to fosinoprilat, its principle active metabolite. Fosinoprilat inhibits ACE, the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Fosinopril may be used to treat mild to moderate hypertension, as an adjunct in the treatment of congestive heart failure, and to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

Fosinopril mechanism of action

There are two isoforms of ACE: the somatic isoform, which exists as a glycoprotein comprised of a single polypeptide chain of 1277; and the testicular isoform, which has a lower molecular mass and is thought to play a role in sperm maturation and binding of sperm to the oviduct epithelium. Somatic ACE has two functionally active domains, N and C, which arise from tandem gene duplication. Although the two domains have high sequence similarity, they play distinct physiological roles. The C-domain is predominantly involved in blood pressure regulation while the N-domain plays a role in hematopoietic stem cell differentiation and proliferation. ACE inhibitors bind to and inhibit the activity of both domains, but have much greater affinity for and inhibitory activity against the C-domain. Fosinoprilat, the active metabolite of fosinopril, competes with ATI for binding to ACE and inhibits and enzymatic proteolysis of ATI to ATII. Decreasing ATII levels in the body decreases blood pressure by inhibiting the pressor effects of ATII as described in the Pharmacology section above. Fosinoprilat also causes an increase in plasma renin activity likely due to a loss of feedback inhibition mediated by ATII on the release of renin and/or stimulation of reflex mechanisms via baroreceptors.

Dosage forms of Fosinopril

Fosinopril10mg100 Tablet$69.00
Fosinopril20mg100 Tablet$79.00
Monopril10mg84 Tablet$106.00
Monopril20mg100 Tablet$116.00
Monopril HCTZ10/12.5mg84 Tablet$90.00
Monopril HCTZ20/12.5mg84 Tablet$116.00

Prescription Generics


International Brands



(2S,4S)-4-Cyclohexyl-1-(2-((2-methyl-1-propanoyloxypropoxy)-(4-phenylbutyl)phosphoryl)acetyl)pyrrolidine-2-carboxylic acid (2S,4S)-4-Cyclohexyl-1-{2-((2-methyl-1-propionyloxy-propoxy)-(4-phenyl-butyl)-phosphinoyl)-acetyl}-pyrrolidine-2-carboxylic acid


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Fosinopril

For treating mild to moderate hypertension, use as an adjunct in treating congestive heart failure, and may be used to slow the rate of progression of renal disease in hypertensive individuals with diabetes mellitus and microalbuminuria or overt nephropathy.

Toxicity of Fosinopril

Human overdoses of fosinopril have not been reported, but the most common manifestation of human fosinopril overdosage is likely to be hypotension. Oral doses of fosinopril at 2600 mg/kg in rats were associated with significant lethality. The most common adverse effects include dizzines, cough, fatigue, and headache.

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