Save up -80% on Fosphenytoin

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Fosphenytoin

Cerebyx 500 mg pe/10 ml vial

$8.63ml
price without discount in nearest pharmacy. Price may vary.

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Fosphenytoin volume of distribution

* 4.3 to 10.8 L

RX Prescription
Ask Your therapeut before taking any drugs.

About RX24Drugs

2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Fosphenytoin

Fosphenytoin is a water-soluble phenytoin prodrug used only in hospitals for the treatment of epileptic seizures. It works by slowing down impulses in the brain that cause seizures. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

Fosphenytoin mechanism of action

Fosphenytoin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

Dosage forms of Fosphenytoin

FormRouteStrength
Liquidintramuscular; intravenous75 mg
Injectionintramuscular; intravenous50 mg/mL
Injection, solutionintramuscular; intravascular50 mg/mL

Prescription Generics

false

International Brands

Cerebyx

Synonyms

(3-Phosphoryloxymethyl)phenytoin Cerebyx

Manufacturers

Pfizer Laboratories

CAS number

93390-81-9

UNII

B4SF212641

State

solid

Affected organisms

Humans and other mammals

Indication of Fosphenytoin

For the control of generalized convulsive status epilepticus and prevention and treatment of seizures occurring during neurosurgery. It can also be substituted, short-term, for oral phenytoin.

Toxicity of Fosphenytoin

Nausea, vomiting, lethargy, tachycardia, bradycardia, asystole, cardiac arrest, hypotension, syncope, hypocalcemia, metabolic acidosis, and death have been reported in cases of overdosage with fosphenytoin. The median lethal dose of fosphenytoin given intravenously in mice and rats was 156 mg PE/kg and approximately 250 mg PE/kg, or about 0.6 and 2 times, respectively, the maximum human loading dose on a mg/m2 basis. Signs of acute toxicity in animals included ataxia, labored breathing, ptosis, and hypoactivity.

RX24 Drugs Disclaimer: before buying a Fosphenytoin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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