Save up -80% on Frovatriptan

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Frovatriptan

Frova 2.5 mg tablet

$33.73tablet
price without discount in nearest pharmacy. Price may vary.

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Frovatriptan volume of distribution

* 4.2 L/kg (males) * 3 L/kg (females)

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Frovatriptan

Frovatriptan (Frova) is a triptan drug developed by Vernalis for the treatment of migraine headaches, in particular those associated with menstruation. The product is licensed to Endo Pharmaceuticals in North America and Menarini in Europe.(1) Frovatriptan causes vasoconstriction of arteries and veins that supply blood to the head. It is available as 2.5 mg tablets. Frovatriptan has mean terminal elimination half-life of approximately 26 hours, which is substantially longer than other triptans. Frovatriptan is available only by prescription in the United States, where a secondary New Drug Approval (sNDA) was filed in July 2006(2) and which is currently pending.(3) The FDA anticipates completing its review of this application on or before the current PDUFA (Prescription Drug User Fee Act) review date of August 19, 2007. If the sNDA is approved, Frova will be the only medication indicated in the U.S. for the short-term prevention of menstrual migraine (MM).

Frovatriptan mechanism of action

Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans: (1) stimulation of presynaptic 5-HT sub 1D /sub receptors, which serves to inhibit both dural vasodilation and inflammation; (2) direct inhibition of trigeminal nuclei cell excitability via 5-HT sub 1B/1D /sub receptor agonism in the brainstem and (3) vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT sub 1B /sub receptor agonism.

Dosage forms of Frovatriptan

FormRouteStrength
Tabletoral2.5 mg
Tablet, film coatedoral2.5 mg/1

Prescription Generics

false

International Brands

Frova

Synonyms

Allergo filmtabletten Frovatriptan succinate

Manufacturers

Lake Erie Medical DBA Quality Care Products LLC

CAS number

158747-02-5

UNII

H82Q2D5WA7

State

solid

Affected organisms

Humans and other mammals

Indication of Frovatriptan

For the acute treatment of migraine attacks with or without aura in adults.

Toxicity of Frovatriptan

There is no direct experience of any patient taking an overdose of Frovatriptan. The maximum single dose of frovatriptan given to male and female patients with migraine was 40 mg (16 times the clinical dose) and the maximum single dose given to healthy male subjects was 100 mg (40 times the clinical dose) without significant adverse events.

RX24 Drugs Disclaimer: before buying a Frovatriptan on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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