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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lasix

$33.5630 tablets/40mg
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Furosemide volume of distribution

The apparently smaller volume of distribution in the cardiac patients (0.140 1/kg and 0.181 1/kg, respectively) was not significantly different. In the group of normal subjects, whose ages ranged from 27 to 74 years, no correlation was found between age and either plasma clearance or volume of distribution. In all the patients, the renal clearance of furosemide rose from the first to the second hour after the injection (average +/- SD)–39 +/- 17 and 77 +/- 51 ml/min.

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What is Furosemide

A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency.

Furosemide mechanism of action

Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic.

Dosage forms of Furosemide

Furosemide20mg100 Scored Tablet$35.00
Furosemide40mg28 Tablet$18.00
Furosemide40mg84 Tablet$36.00
Furosemide80mg100 Scored Tablet$45.00
Lasix40mg90 Tablet$21.40
Lasix10mg/mL120mL Oral solution$62.50

Prescription Generics


International Brands

Apo Furosemide Tab 20mg


2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid


Apotex Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Furosemide

For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.

Toxicity of Furosemide

Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.

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