Save up -80% on Furosemide
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|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Lasix
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Furosemide volume of distribution
The apparently smaller volume of distribution in the cardiac patients (0.140 1/kg and 0.181 1/kg, respectively) was not significantly different. In the group of normal subjects, whose ages ranged from 27 to 74 years, no correlation was found between age and either plasma clearance or volume of distribution. In all the patients, the renal clearance of furosemide rose from the first to the second hour after the injection (average +/- SD)–39 +/- 17 and 77 +/- 51 ml/min.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Furosemide
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency.
Furosemide mechanism of action
Furosemide, a loop diuretic, inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This is achieved through competitive inhibition at the chloride binding site on the cotransporter, thus preventing the transport of sodium from the lumen of the loop of Henle into the basolateral interstitium. Consequently, the lumen becomes more hypertonic while the interstitium becomes less hypertonic, which in turn diminishes the osmotic gradient for water reabsorption throughout the nephron. Because the thick ascending limb is responsible for 25% of sodium reabsorption in the nephron, furosemide is a very potent diuretic.
Dosage forms of Furosemide
|Furosemide||20mg||100 Scored Tablet||$35.00|
|Furosemide||80mg||100 Scored Tablet||$45.00|
|Lasix||10mg/mL||120mL Oral solution||$62.50|
Apo Furosemide Tab 20mg
2-Furfurylamino-4-chloro-5-sulfamoylbenzoic acid 4-Chloro-5-sulfamoyl-N-furfuryl-anthranilic acid
Humans and other mammals
Indication of Furosemide
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Toxicity of Furosemide
Profound diuresis may cause fluid and electrolyte depletion. Excessive dehydration and potassium depletion may occur. Excessive diuresis may cause rapid weight loss, orthostatic hypotension or acute hypotensive episodes. May also cause tinnitus, reversible or permanent hearing loss or reversible deafness.
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