Save up -80% on Gabapentin

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Gabapentin

Gabapentin 300 mg Capsule

$1.02

capsule

* price without discount in nearest pharmacy. Price may vary.

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Gabapentin volume of distribution

* 586 L

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What is Gabapentin

Gabapentin (brand name Neurontin) is a medication originally developed for the treatment of epilepsy. Presently, gabapentin is widely used to relieve pain, especially neuropathic pain. Gabapentin is well tolerated in most patients, has a relatively mild side-effect profile, and passes through the body unmetabolized.

Gabapentin mechanism of action

Gabapentin interacts with cortical neurons at auxillary subunits of voltage-sensitive calcium channels. Gabapentin increases the synaptic concentration of GABA, enhances GABA responses at non-synaptic sites in neuronal tissues, and reduces the release of mono-amine neurotransmitters. One of the mechanisms implicated in this effect of gabapentin is the reduction of the axon excitability measured as an amplitude change of the presynaptic fibre volley (FV) in the CA1 area of the hippocampus. This is mediated through its binding to presynaptic NMDA receptors. Other studies have shown that the antihyperalgesic and antiallodynic effects of gabapentin are mediated by the descending noradrenergic system, resulting in the activation of spinal alpha2-adrenergic receptors. Gabapentin has also been shown to bind and activate the adenosine A1 receptor.

Dosage forms of Gabapentin

FormRouteStrength
Kittopical
Kitoral
Capsuleoral100 mg/1
Prescription Generics

false

International Brands

Act Gabapentin

Synonyms

1-(Aminomethyl)cyclohexaneacetic acid Gabapentin GR

Manufacturers

Actavis Pharma Company

CAS number

60142-96-3

UNII

6CW7F3G59X

State

solid

Affected organisms

Humans and other mammals

Indication of Gabapentin

For the management of postherpetic neuralgia in adults and as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.

Toxicity of Gabapentin

Symptoms of overdose include ataxia, labored breathing, ptosis, sedation, hypoactivity, and excitation.

RX24 Drugs Disclaimer: before buying a Gabapentin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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