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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Gadoxetic acid volume of distribution

Total volume of distribution at steady state is 0.21 L/kg. Gadoxetate disodium cannot diffuse through the blood brain barrier. The two transporters that gadoxetate disodium can enter the hepatocyte through are OATP1B1 and OATP1B3. Gadoxetate disodium may also exit the heptaocyte and go back into sinusoidal space via active transport through multidrug resistance protein 3 and 4.

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What is Gadoxetic acid

Gadoxetic acid (gadoxetate) is a paramagnetic gadolinium-containing contrast agent in which its salt form, gadoxetate disodium, is used for intravenous injection. Ethoxybenzyl diethylenetriaminepentaacetic acid is the moiety that chelates with a gadolinium ion and forms a stable complex with it to make up the drug. It is marketed by Bayer HealthCare Pharmaceuticals and FDA approved on July 3, 2008.

Gadoxetic acid mechanism of action

When gadoxetate disodium is placed in an external magnetic field, a large magnetic moment is produced. As a result, a magnetic field is induced around the tissue. The water protons in the vicinity are disrupted such that the change the proton density and spin characteristics are detected and visualized by a device.

Dosage forms of Gadoxetic acid

FormRouteStrength
Injection, solutionintravenous181.43 mg/mL
Solutionintravenous181.43 mg

Prescription Generics

false

International Brands

Eovist

Synonyms

Gadoxetate Gd-EOB-DTPA

Manufacturers

Bayer Health Care Pharmaceuticals Inc.

CAS number

135326-11-3

UNII

3QJA87N40S

State

solid

Affected organisms

Humans and other mammals

Indication of Gadoxetic acid

Gadoxetate is used as a contrast medium for magnetic resonance imaging (MRI) to detect and characterize lesions in the liver.

Toxicity of Gadoxetic acid

LD50, oral, rat = 18100 mg/kg; LD50, oral, mouse = 14500 mg/kg; LD50, IV, rat = 3600 – 7300 mg/kg; LD50, IV, mouse = 5400 – 10900 mg/kg; LD50, IV, dog = 2200 mg/kg

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