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Price of Galantamine
Galantamine hbr 12 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Galantamine volume of distribution
* 175 L
What is Galantamine
A benzazepine derived from norbelladine. It is found in galanthus and other amaryllidaceae. Galantamine is a cholinesterase inhibitor that has been used to reverse the muscular effects of gallamine triethiodide and tubocurarine, and has been studied as a treatment for Alzheimer’s disease and other central nervous system disorders. (PubChem)
Galantamine mechanism of action
Galantamine is a phenanthrene alkaloid and a reversible, competitive acetylcholinesterase inhibitor. It is not structurally related to other acetylcholinesterase inhibitors. Galantamine’s proposed mechanism of action involves the reversible inhibition of acetylcholinesterase, which prevents the hydrolysis of acetycholine, leading to an increased concentration of acetylcholine at cholinergic synapses. Galantamine also binds allosterically with nicotinic acetylcholine receptors and may possibly potentiate the action of agonists (such as acetylcholine) at these receptors.
Dosage forms of Galantamine
Humans and other mammals
Indication of Galantamine
For the treatment of mild to moderate dementia of the Alzheimer’s type. Has also been investigated in patients with mild cognitive impairment who did not meet the diagnostic criteria for Alzheimer’s disease.
Toxicity of Galantamine
LD sub50 /sub=75 mg/kg (rat)
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