Save up -80% on Galsulfase
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Galsulfase
Naglazyme 5 mg/5 ml vial
|price without discount in nearest pharmacy. Price may vary.|
We offer free Galsulfase coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Galsulfase every time. What are you waiting for? Claim your prescription drug card now!
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Galsulfase volume of distribution
Week 1: 56-323 mL/kg and 59-2799 mL/kg by week 24
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Galsulfase
Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.
Galsulfase mechanism of action
Galsulfase supplies recombinant-engineered galsulfase, a normal variant form of the polymorphic human enzyme, N-acetylgalactosamine 4-sulfatase. It is a lysosomal hydrolase that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4-sulfate and dermatan sulfate. Increased catabolism of GAG in turn reduces systemic dermatan sulfate accumulation, thereby reducing the primary symptoms of MPS VI.
Dosage forms of Galsulfase
|Concentrate for solution for infusion||Intravenous use||1 mg/ml|
ARSB Arylsufatase B
Biomarin Pharmaceutical Inc
Humans and other mammals
Indication of Galsulfase
For the treatment of adults and children with Mucopolysaccharidosis VI.
Toxicity of Galsulfase
There is no experience with overdose of galsulfase.
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