Save up -80% on Galsulfase

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Galsulfase

Naglazyme 5 mg/5 ml vial

$391.2ml
price without discount in nearest pharmacy. Price may vary.

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Galsulfase volume of distribution

Week 1: 56-323 mL/kg and 59-2799 mL/kg by week 24

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Galsulfase

Galsufase is a variant form of the polymorphic human enzyme N-acetylgalactosamine 4-sulfatase of recombinant DNA origin. Galsulfase is a glycoprotein with a molecular weight of approximately 56 kD. The recombinant protein is comprised of 495 amino acids and contains six asparagine-linked glycosylation sites, four of which carry a bis mannose-6-phosphate manose7 oligosaccharide for specific cellular recognition. Post-translational modification of Cys53 produces the catalytic amino acid residue Ca-formylglycine, which is required for enzyme activity and is conserved in all members of the sulfatase enzyme family.

Galsulfase mechanism of action

Galsulfase supplies recombinant-engineered galsulfase, a normal variant form of the polymorphic human enzyme, N-acetylgalactosamine 4-sulfatase. It is a lysosomal hydrolase that catalyzes the cleavage of the sulfate ester from terminal N-acetylgalactosamine 4-sulfate residues of GAG chondroitin 4-sulfate and dermatan sulfate. Increased catabolism of GAG in turn reduces systemic dermatan sulfate accumulation, thereby reducing the primary symptoms of MPS VI.

Dosage forms of Galsulfase

FormRouteStrength
Concentrate for solution for infusionIntravenous use1 mg/ml
Solutionintravenous1 mg
Solutionintravenous5 mg/5mL

Prescription Generics

false

International Brands

Naglazyme

Synonyms

ARSB Arylsufatase B

Manufacturers

Biomarin Pharmaceutical Inc

CAS number

552858-79-4

UNII

59UA429E5G

State

solid

Affected organisms

Humans and other mammals

Indication of Galsulfase

For the treatment of adults and children with Mucopolysaccharidosis VI.

Toxicity of Galsulfase

There is no experience with overdose of galsulfase.

RX24 Drugs Disclaimer: before buying a Galsulfase on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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