Save up -80% on Ganciclovir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Cytovene
|$1,667.88||8 vials (10ml)/500 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Ganciclovir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Ganciclovir every time. What are you waiting for? Claim your prescription drug card now!
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Ganciclovir volume of distribution
* 0.74 0.15 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Ganciclovir
An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.
Ganciclovir mechanism of action
Ganciclovir’s antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK). TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes. i In vitro /i , ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, ganciclovir triphosphate competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.
Dosage forms of Ganciclovir
|Powder for solution||intravenous||500 mg|
|Injection, powder, lyophilized, for solution||intravenous||500 mg/10mL|
Cytovene – Cap 250mg
Hoffmann La Roche Limited
Human Herpes Virus
Indication of Ganciclovir
For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.
Toxicity of Ganciclovir
Oral, mouse LD sub 50 /sub : 2g/kg. Intravenous, dog LD sub 50 /sub : 150mg/kg. Symptoms of overdose include irreversible pancytopenia, worsening GI symptoms, and acute renal failure. Suspected cancer agent.
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