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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Ganciclovir

Ganciclovir 250 mg capsule

$4.72

capsule

* price without discount in nearest pharmacy. Price may vary.

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Ganciclovir volume of distribution

* 0.74 0.15 L/kg

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What is Ganciclovir

An acyclovir analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections.

Ganciclovir mechanism of action

Ganciclovir’s antiviral activity inhibits virus replication. This inhibitory action is highly selective as the drug must be converted to the active form by a virus-encoded cellular enzyme, thymidine kinase (TK). TK catalyzes phosphorylation of ganciclovir to the monophosphate, which is then subsequently converted into the diphosphate by cellular guanylate kinase and into the triphosphate by a number of cellular enzymes. i In vitro /i , ganciclovir triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, ganciclovir triphosphate competitively inhibits dATP leading to the formation of ‘faulty’ DNA. This is where ganciclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. Ganciclovir inhibits viral DNA polymerases more effectively than it does cellular polymerase, and chain elongation resumes when ganciclovir is removed.

Dosage forms of Ganciclovir

FormRouteStrength
Capsuleoral250 mg
Powder for solutionintravenous500 mg
Injection, powder, lyophilized, for solutionintravenous500 mg/10mL
Prescription Generics

false

International Brands

Cytovene – Cap 250mg

Synonyms

2-(6-Amino-purin-9-ylmethoxy)-propane-1,3-diol 2-amino-9-((1,3-Dihydroxypropan-2-yloxy)methyl)-1H-purin-6(9H)-one

Manufacturers

Hoffmann La Roche Limited

CAS number

82410-32-0

UNII

P9G3CKZ4P5

State

solid

Affected organisms

Human Herpes Virus

Indication of Ganciclovir

For induction and maintenance in the treatment of cytomegalovirus (CMV) retinitis in immunocompromised patients, including patients with acquired immunodeficiency syndrome (AIDS). Also used in the treatment of severe cytomegalovirus (CMV) disease, including CMV pneumonia, CMV gastrointestinal disease, and disseminated CMV infections, in immunocompromised patients.

Toxicity of Ganciclovir

Oral, mouse LD sub 50 /sub : 2g/kg. Intravenous, dog LD sub 50 /sub : 150mg/kg. Symptoms of overdose include irreversible pancytopenia, worsening GI symptoms, and acute renal failure. Suspected cancer agent.

RX24 Drugs Disclaimer: before buying a Ganciclovir on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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