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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Iressa

$7,643.0530 tablets/250mg
Price with discount in nearest pharmacy. Price may vary.

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Gefitinib volume of distribution

The intravenous pharmacokinetics of gefitinib demonstrated that the drug is extensively distributed into the body tissues and is rapidly cleared from the plasma, with a mean steady state volume of distribution of 1,400 L 3 In the present studies, it was also noticed that gefitinib was distributed extensively throughout the body with a distribution volume of 1,502-2,219 L. Clearance of a drug by the liver depends on the liver blood flow and the ability of the liver to metabolize the drug, i.e., the hepatic extraction ratio. The liver metabolic abnormalities in cancer patients may be one of the main reasons for a lower clearance of gefitinib; therefore, a higher t 1/2 is observed in cancer patients than in healthy subjects.

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2018 Statistics

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What is Gefitinib

Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa. (Wikipedia)

Gefitinib mechanism of action

Gefitinib inhibits the epidermal growth factor receptor (EGFR) tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme. Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited; and malignant cells are inhibited. Gefitinib is the first selective inhibitor of the EGFR tyrosine kinase which is also referred to as Her1 or ErbB-1. EGFR is overexpressed in the cells of certain types of human carcinomas – for example in lung and breast cancers. Overexpression leads to inappropriate activation of the apoptotic Ras signal transduction cascade, eventually leading to uncontrolled cell proliferation.

Dosage forms of Gefitinib

Film-coated tabletOral use250 mg
Tabletoral250 mg
Tablet, coatedoral250 mg/1

Prescription Generics


International Brands



4-(3′-chloro-4′-Fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline Gefitinib


Astra Zeneca Pharmaceuticals Lp

CAS number






Affected organisms

Humans and other mammals

Indication of Gefitinib

For the continued treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of either platinum-based or docetaxel chemotherapies.

Toxicity of Gefitinib

The acute toxicity of gefitinib up to 500 mg in clinical studies has been low. In non-clinical studies, a single dose of 12,000 mg/m sup 2 /sup (about 80 times the recommended clinical dose on a mg/m sup 2 /sup basis) was lethal to rats. Half this dose caused no mortality in mice. Symptoms of overdose include diarrhea and skin rash.

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