Save up -80% on Gemcitabine

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Gemcitabine

Gemzar 200 mg Solution Vial

$180.78

vial

* price without discount in nearest pharmacy. Price may vary.

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Gemcitabine volume of distribution

* 50 L/m^2 (infusions lasting 70 minutes) * 370 L/m^2 (long infusions)

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What is Gemcitabine

Gemcitabine is a nucleoside analog used as chemotherapy. It is marketed as Gemzar by Eli Lilly and Company. As with fluorouracil and other analogues of pyrimidines, the drug replaces one of the building blocks of nucleic acids, in this case cytidine, during DNA replication. The process arrests tumor growth, as new nucleosides cannot be attached to the “faulty” nucleoside, resulting in apoptosis (cellular “suicide”). Gemcitabine is used in various carcinomas: non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. It is being investigated for use in oesophageal cancer, and is used experimentally in lymphomas and various other tumor types.

Gemcitabine mechanism of action

Gemcitabine inhibits thymidylate synthetase, leading to inhibition of DNA synthesis and cell death. Gemcitabine is a prodrug so activity occurs as a result of intracellular conversion to two active metabolites, gemcitabine diphosphate and gemcitabine triphosphate by deoxycitidine kinase. Gemcitabine diphosphate also inhibits ribonucleotide reductase, the enzyme responsible for catalyzing synthesis of deoxynucleoside triphosphates required for DNA synthesis. Finally, Gemcitabine triphosphate (diflurorodeoxycytidine triphosphate) competes with endogenous deoxynucleoside triphosphates for incorporation into DNA.

Dosage forms of Gemcitabine

FormRouteStrength
Injectionintravenous38 mg/mL
Injection, powder, lyophilized, for solutionintravenous1 g/26.3mL
Injection, powder, lyophilized, for solutionintravenous200 mg/5.26mL
Prescription Generics

false

International Brands

Act Gemcitabine

Synonyms

2′-Deoxy-2′,2′-difluorocytidine 2′,2′-Difluorodeoxycytidine

Manufacturers

Actavis Pharma Company

CAS number

95058-81-4

UNII

B76N6SBZ8R

State

solid

Affected organisms

Humans and other mammals

Indication of Gemcitabine

Gemcitabine is indicated for the treatment of advanced ovarian cancer that has relapsed at least 6 months after completion of platinum-based therapy; metastatic ovarian cancer; inoperable, locally advanced (Stage IIIA or IIIB), or metastatic (Stage IV) non-small cell lung cancer; and locally advanced (nonresectable Stage II or Stage III) or metastatic (Stage IV) adenocarcinoma of the pancreas.

Toxicity of Gemcitabine

Myelosuppression, paresthesias, and severe rash were the principal toxicities, LD sub50 /sub=500 mg/kg (orally in mice and rats)

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