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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Lopid

$11.860 tablets/600 mg
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Gemfibrozil volume of distribution

This increase in half-life we noted (i.e. reduction in λz) likely contributed to the increase in apparent volume of distribution (V/F) we observed compared to previously reported values (37L vs approximately 10 L for a 70 kg individual) since V/F was estimated as dose divided by the product of AUC0-∞ and λz.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Gemfibrozil

A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established.

Gemfibrozil mechanism of action

Gemfibrozil increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. It does so by activating Peroxisome proliferator-activated receptor-alpha (PPAR.) ‘transcription factor ligand’, a receptor that is involved in metabolism of carbohydrates and fats, as well as adipose tissue differentiation. This increase in the synthesis of lipoprotein lipase thereby increases the clearance of triglycerides. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Gemfibrozil also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL.

Dosage forms of Gemfibrozil

FormRouteStrength
Tabletoral600 mg
Capsuleoral300 mg
Tabletoral600 mg/1

Prescription Generics

true

International Brands

Apo-gemfibrozil

Synonyms

2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeriansaeure 2,2-Dimethyl-5-(2,5-xylyloxy)valeriansaeure

Manufacturers

Apotex Inc

CAS number

25812-30-0

UNII

Q8X02027X3

State

solid

Affected organisms

Humans and other mammals

Indication of Gemfibrozil

For treatment of adult patients with very high elevations of serum triglyceride levels (types IV and V hyperlipidemia) who are at risk of developing pancreatitis (inflammation of the pancreas) and who do not respond adequately to a strict diet.

Toxicity of Gemfibrozil

Oral, mouse: LD sub50 /sub = 3162 mg/kg. Symptoms of overdose include abdominal cramps, diarrhea, joint and muscle pain, nausea, and vomiting.

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