Save up -80% on Gentamicin
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2018 Price of Gentamicin
Garamycin 0.3 % Ointment
* price without discount in nearest pharmacy. Price may vary.
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Gentamicin volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Gentamicin
A complex of three different closely related aminoglycoside sulfates, Gentamicins C1, C2, and C1a, obtained from Micromonospora purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit protein synthesis (genetic translation).
Gentamicin mechanism of action
Aminoglycosides like gentamicin “irreversibly” bind to specific 30S-subunit proteins and 16S rRNA. Specifically gentamicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Dosage forms of Gentamicin
|Liquid||intramuscular; intravenous||40 mg|
|Liquid||intramuscular; intravenous||10 mg|
Alcomicin Oph Sol 3mg/ml
Alcon Canada Inc
Enteric bacteria and other eubacteria
Indication of Gentamicin
For treatment of serious infections caused by susceptible strains of the following microorganisms: iP. aeruginosa/i, iProteus/i species (indole-positive and indole-negative), iE. coli/i, iKlebsiella-Enterobactor-Serratia/i species, iCitrobacter/i species and iStaphylococcus/i species (coagulase-positive and coagulase-negative).
Toxicity of Gentamicin
Mild and reversible nephrotoxicity may be observed in 5 – 25% of patients. Gentamicin accumulates in proximal renal tubular cells and causes cell damage. Tubular cell regeneration occurs despite continued drug exposure. Toxicity usually occurs several days following initiation of therapy. May cause irreversible ototoxicity. Otoxocity appears to be correlated to cumulative lifetime exposure. Drug accumulation in the endolymph and perilymph of the inner ear causes irreversible damage to hair cells of the cochlea or summit of ampullar cristae in the vestibular complex. High frequency hearing is lost first with progression leading to loss of low frequency hearing. Further toxicity may lead to retrograde degeneration of the 8th cranial (vestibulocochlear) nerve. Vestibular toxicity may cause vertigo, nausea, vomiting, dizziness and loss of balance. Mouse, intravenous LD50: 52 mg/kg; rat, intravenous LD50: 96 mg/kg.
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