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Price of Gentian Violet
Gentian violet 1% solution
* price without discount in nearest pharmacy. Price may vary.
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Gentian Violet volume of distribution
What is Gentian Violet
A dye that is a mixture of violet rosanilinis with antibacterial, antifungal, and anthelmintic properties. (PubChem)
Gentian Violet mechanism of action
In aqueous solutions Gentian violet (GV) dissociates into positive (GV+)and negative ions (Cl-) that penetrate through the wall and membrane of both gram-positive and gram-negative bacterial cells. The GV+ interacts with negatively charged components of bacterial cells including the lipopolysaccharide (on the cell wall), the peptidoglycan and DNA. A similar cell penetration and DNA binding process is thought to take place for fungal cells as well. Because Gentian violet is a mutagen and mitotic poison, cell growth is consequently inhibited. A photodynamic action of gentian violet, apparently mediated by a free-radical mechanism, has recently been described in bacteria and in the protozoan T. cruzi. Evidence also suggests that gentian violet dissipates the bacterial (and mitochondrial) membrane potential by inducing permeability. This is followed by respiratory inhibition. This anti-mitochondrial activity might explain gentian violet’s efficacy towards both bacteria and yeast with relatively mild effects on mammalian cells.
Dosage forms of Gentian Violet
De LA Cruz Gentian Violet
Crystal violet carbocation
DLC Laboratories, Inc.
Yeast and other fungi
Indication of Gentian Violet
For the treatment of bacterial and fungal infections inside the mouth (thrush) and skin, also for the prevention of transmission of Chagas’ disease (as a blood additive).
Toxicity of Gentian Violet
LD sub50 /sub=420 mg/kg (rat, oral). Oral administration can cause gastrointestinal irritation, and intravenous injection can cause depression in the white blood cell count.
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