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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Glatiramer Acetate

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Glatiramer Acetate volume of distribution

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What is Glatiramer Acetate

Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis

Glatiramer Acetate mechanism of action

Glatiramer acetate (GA) exhibits strong and promiscuous binding to MHC molecules (HLA DRB1* variants) and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression. Furthermore, the GA-specific cells in the brain express the anti-inflammatory cytokines IL-10 and transforming growth factor beta, in addition to brain-derived neurotrophic factor, whereas they do not express the inflammatory cytokine IFN-gamma. Recent evidence also suggests that Glatiramer acetate directly inhibits dendritic cells and monocytes – both of which are circulating antigen presenting cells.

Dosage forms of Glatiramer Acetate

Injection, solutionsubcutaneous40 mg/mL
Powder for solutionsubcutaneous20 mg
Solutionsubcutaneous20 mg
Prescription Generics


International Brands



COP-1 Copolymer-1


Teva Canada Limited

CAS number






Affected organisms

Humans and other mammals

Indication of Glatiramer Acetate

For reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.

Toxicity of Glatiramer Acetate

Adverse reactions include injection site reactions, vasodilatation, chest pain, asthenia, infection, pain, nausea, arthralgia, anxiety, and hypertonia.

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