Save up -80% on Glatiramer Acetate
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2018 Price of Glatiramer Acetate
Copaxone 20 mg injection kit
* price without discount in nearest pharmacy. Price may vary.
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Glatiramer Acetate volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Glatiramer Acetate
Glatiramer acetate consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively. The average molecular weight of glatiramer acetate is 5,000-9,000 daltons. It is an immunomodulator, licensed in much of the world for reduced frequency of relapses in relapsing-remitting multiple sclerosis
Glatiramer Acetate mechanism of action
Glatiramer acetate (GA) exhibits strong and promiscuous binding to MHC molecules (HLA DRB1* variants) and consequent competition with various myelin antigens for their presentation to T cells. A further aspect of its action is potent induction of specific suppressor cells of the T helper 2 (Th2) type that migrate to the brain and lead to in situ bystander suppression. Furthermore, the GA-specific cells in the brain express the anti-inflammatory cytokines IL-10 and transforming growth factor beta, in addition to brain-derived neurotrophic factor, whereas they do not express the inflammatory cytokine IFN-gamma. Recent evidence also suggests that Glatiramer acetate directly inhibits dendritic cells and monocytes – both of which are circulating antigen presenting cells.
Dosage forms of Glatiramer Acetate
|Injection, solution||subcutaneous||40 mg/mL|
|Powder for solution||subcutaneous||20 mg|
Teva Canada Limited
Humans and other mammals
Indication of Glatiramer Acetate
For reduction of the frequency of relapses in patients with Relapsing-Remitting Multiple Sclerosis.
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